| CPC G01N 27/3274 (2013.01) [A61B 5/14532 (2013.01); A61B 5/1495 (2013.01); A61B 2560/0223 (2013.01)] | 22 Claims |
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1. A method for self-calibration of an analyte sensor system that includes a glucose sensor operatively coupled to sensor electronics, the method comprising:
applying a bias voltage with the sensor electronics to generate sensor data, the analyte sensor system having an initial characteristic metric determined at a first time;
using the sensor electronics at a second time subsequent to the first time to determine a change to the initial characteristic metric of the analyte sensor system based at least in part on a humidity associated with the glucose sensor while the glucose sensor is within a sterile package;
storing a relationship between impedance and humidity in a memory associated with the sensor electronics;
monitoring the humidity associated with the glucose sensor while the glucose sensor is within the sterile package, wherein the humidity is monitored between the first time and second time, the monitoring comprising:
applying a stimulus signal to at least one of a first electrode or a second electrode of the glucose sensor while the glucose sensor is within the sterile package;
measuring a signal response to the stimulus signal applied while the glucose sensor is within the sterile package;
calculating the impedance based on the signal response to the stimulus signal applied while the glucose sensor is within the sterile package;
determining a value for the humidity within the sterile package based on the calculated impedance and the relationship between impedance and humidity stored in the memory; and
determining, based at least on the calculated impedance, a duration of exposure of the glucose sensor to the value for the humidity while the glucose sensor is within the sterile package;
using the sensor electronics to automatically calibrate, without user intervention, the analyte sensor system based at least in part on the value for the humidity and the duration of exposure of the glucose sensor to the value for the humidity while the glucose sensor is within the sterile package, the automatically calibrating comprising determining an updated calibration factor; and
automatically applying the updated calibration factor, without user intervention, to a signal generated by the first electrode and the second electrode to determine a glucose concentration during use of the glucose sensor, wherein the glucose sensor is used after removal of the glucose sensor from the sterile package and after at least the stimulus signal is applied to at least one of the first electrode or the second electrode of the glucose sensor while the glucose sensor is within the sterile package.
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