	US 12,258,607 B2
	Methods for a controlled coenzyme Q₁₀fermentation production process
Guanghuang Zhan, Xiamen (CN); Yi Wu, Xiamen (CN); Biqin Chen, Xiamen (CN); Zhichun Zhu, Xiamen (CN); and Dan Li, Xiamen (CN)
Assigned to INNER MONGOLIA KINGDOMWAY PHARMACEUTICAL CO., LTD., Hohhot (CN); and XIAMEN KINGDOMWAY GROUP COMPANY, Xiamen (CN)
Filed by INNER MONGOLIA KINGDOMWAY PHARMACEUTICAL CO., LTD., Inner Mongolia (CN); and XIAMEN KINGDOMWAY GROUP COMPANY, Fujian (CN)
Filed on Feb. 20, 2023, as Appl. No. 18/171,647.
Application 18/171,647 is a continuation of application No. 16/599,184, filed on Oct. 11, 2019, granted, now 11,584,942.
Application 16/599,184 is a continuation of application No. PCT/CN2019/085990, filed on May 8, 2019.
Prior Publication US 2023/0203543 A1, Jun. 29, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C12P 7/26 (2006.01); C12N 1/20 (2006.01)

CPC C12P 7/26 (2013.01) [C12N 1/20 (2013.01)]

20 Claims

1. A coenzyme Q₁₀fermentation production process, comprising:

growing a microbial culture of bacteria in a first tank by providing a carbon source and an oxygen source;

monitoring a first fermentation parameter of the microbial culture in the first tank, the first fermentation parameter including at least one of a concentration of carbon dioxide in an exhaust gas of the microbial culture or a concentration of lactate in the microbial culture;

determining whether the first fermentation parameter of the microbial culture in the first tank satisfies a first condition;

in response to a determination that the first fermentation parameter does not satisfy the first condition,

adjusting the first fermentation parameter by performing one or more operations, the one or more operations including increasing or decreasing a rotor speed, a tank pressure, or an air supply rate.