US 12,258,563 B2
Modified oligonucleotides
Darren H. Wakefield, Fitchburg, WI (US); Lauren Almeida, Madison, WI (US); David Rozema, Cross Plains, WI (US); Omri Gottesman, San Diego, CA (US); and David Lewis, Madison, WI (US)
Assigned to EMPIRICO INC., San Diego, CA (US)
Filed by EMPIRICO INC., San Diego, CA (US)
Filed on Mar. 27, 2023, as Appl. No. 18/190,819.
Claims priority of provisional application 63/324,487, filed on Mar. 28, 2022.
Claims priority of provisional application 63/429,756, filed on Dec. 2, 2022.
Prior Publication US 2023/0304008 A1, Sep. 28, 2023
Int. Cl. A61K 9/00 (2006.01); A61K 31/713 (2006.01); A61K 47/54 (2017.01); C12N 15/113 (2010.01)
CPC C12N 15/113 (2013.01) [A61K 31/713 (2013.01); A61K 47/543 (2017.08); C12N 2310/14 (2013.01); C12N 2310/315 (2013.01); C12N 2310/321 (2013.01); C12N 2310/322 (2013.01); C12N 2310/3515 (2013.01)] 19 Claims
 
1. A composition comprising:
a small interfering RNA (siRNA) comprising a sense strand, an antisense strand, and a
ligand comprising the structure:

OG Complex Work Unit Chemistry
and
wherein the dotted line indicates a connection to the 5′ or 3′ end of the sense or antisense strand, n is 0-3, and R is an alkyl group containing 4-20 carbons.