US 12,258,467 B2
Lubricious structures, methods of making them, and methods of use
Scott S. Perry, Houston, TX (US); Alexander Rudy, Gainesville, FL (US); Wallace Gregory Sawyer, Gainesville, FL (US); and Thomas Ettor Angelini, Gainesville, FL (US)
Assigned to University of Florida Research Foundation, INC., Gainesville, FL (US)
Filed by University of Florida Research Foundation, Inc., Gainesville, FL (US)
Filed on Oct. 26, 2022, as Appl. No. 17/974,079.
Application 17/974,079 is a continuation of application No. 17/166,671, filed on Feb. 3, 2021, granted, now 11,674,029.
Application 17/166,671 is a continuation of application No. 16/327,526, granted, now 11,066,545, issued on Jul. 20, 2021, previously published as PCT/US2017/048649, filed on Aug. 25, 2017.
Claims priority of provisional application 62/379,478, filed on Aug. 25, 2016.
Prior Publication US 2023/0077050 A1, Mar. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C08L 33/26 (2006.01); A61L 29/06 (2006.01); A61L 29/08 (2006.01); A61L 29/14 (2006.01); C08L 33/02 (2006.01); C08L 33/08 (2006.01); C08L 83/04 (2006.01)
CPC C08L 33/26 (2013.01) [A61L 29/06 (2013.01); A61L 29/085 (2013.01); A61L 29/14 (2013.01); C08L 33/02 (2013.01); C08L 33/08 (2013.01); C08L 83/04 (2013.01); A61L 2400/10 (2013.01); C08L 2203/02 (2013.01)] 16 Claims
 
1. A method of making a lubricious structure, comprising:
providing a substrate having a surface;
disposing a coating mixture on the surface of the substrate, wherein the coating mixture includes a physically entangled polymer network, wherein each polymer has a plurality of coupling groups on the main backbone of polymer, wherein the main backbone of the polymer is a polyurethane backbone; and
forming a coating on the substrate, the coating includes the physically entangled polymer network, wherein the physically entangled polymer network is made up of physically interacting chains having a mesh structure that defines the physically entangled polymer network, wherein the mesh structure includes a network of polymer molecules arranged through physical entanglement such that systematic spaces exist within the material between/among the polymer molecular chains, wherein the spaces and voids have the capacity to fill with solvent molecules, wherein there is a covalent bond between the surface of the substrate and one of the plurality of coupling groups.