US 12,258,454 B2
Swellable and structurally homogenous hydrogels and methods of use thereof
Ruixuan Gao, Cambridge, MA (US); Linyi Gao, Cambridge, MA (US); Chih-Chieh Yu, Cambridge, MA (US); and Edward Stuart Boyden, Chestnut Hill, MA (US)
Assigned to Massachusetts Institute of Technology, Cambridge, MA (US)
Filed by Massachusetts Institute of Technology, Cambridge, MA (US)
Filed on Nov. 29, 2023, as Appl. No. 18/523,580.
Application 18/523,580 is a division of application No. 16/267,849, filed on Feb. 5, 2019, granted, now 11,873,374.
Claims priority of provisional application 62/626,920, filed on Feb. 6, 2018.
Prior Publication US 2024/0174818 A1, May 30, 2024
Int. Cl. C08J 3/075 (2006.01); C08F 8/00 (2006.01); C08F 8/12 (2006.01); C08F 8/30 (2006.01); C08F 8/44 (2006.01); C08F 220/04 (2006.01); C08F 220/30 (2006.01); C08F 222/10 (2006.01); C08G 65/26 (2006.01); C08G 65/32 (2006.01); C08G 81/02 (2006.01); C08J 3/24 (2006.01); C12Q 1/68 (2018.01); C12Q 1/6834 (2018.01); C12Q 1/6841 (2018.01); C12Q 1/6869 (2018.01); G01N 1/30 (2006.01); G01N 1/36 (2006.01); G01N 15/0205 (2024.01); G01N 33/545 (2006.01); C08F 220/34 (2006.01)
CPC C08J 3/075 (2013.01) [C08F 8/00 (2013.01); C08F 8/12 (2013.01); C08F 8/30 (2013.01); C08F 8/44 (2013.01); C08F 222/104 (2020.02); C08G 65/2624 (2013.01); C08G 65/32 (2013.01); C08G 81/025 (2013.01); C08J 3/246 (2013.01); C12Q 1/68 (2013.01); C12Q 1/6834 (2013.01); C12Q 1/6841 (2013.01); C12Q 1/6869 (2013.01); G01N 1/30 (2013.01); G01N 33/545 (2013.01); C08F 220/04 (2013.01); C08F 220/303 (2020.02); C08F 220/346 (2020.02); C08F 2438/01 (2013.01); C08G 2210/00 (2013.01); C08J 2300/206 (2013.01); C08J 2400/206 (2013.01); C12Q 2523/101 (2013.01); G01N 1/36 (2013.01); G01N 15/0205 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A hydrogel that is the product of a non-radical polymerization reaction between a monomer of Formula (A5):

OG Complex Work Unit Chemistry
and a monomer of Formula (B1):

OG Complex Work Unit Chemistry
wherein:
each n is an integer greater than or equal to 1;
each p is an integer greater than or equal to 1;
E is a moiety comprising a charged functional group;
Z is a counter ion;
X and Y1 are each crosslinkable moieties; and
X and Y1 covalently crosslink to end-link the monomers.