US 12,258,412 B2
Nucleic acid molecules encoding bispecific anti-BCMA x anti-CD3 antibodies
Eric Smith, New York, NY (US); Kara Olson, White Plains, NY (US); Frank Delfino, Poughquag, NY (US); David DiLillo, New York, NY (US); Jessica Kirshner, New York, NY (US); Olga Sineshchekova, Pleasantville, NY (US); and Qian Zhang, Lexington, MA (US)
Assigned to Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US)
Filed by Regeneron Pharmaceuticals, Inc., Tarrytown, NY (US)
Filed on May 31, 2022, as Appl. No. 17/828,847.
Application 17/828,847 is a continuation of application No. 16/516,028, filed on Jul. 18, 2019, granted, now 11,384,153.
Claims priority of provisional application 62/793,645, filed on Jan. 17, 2019.
Claims priority of provisional application 62/750,968, filed on Oct. 26, 2018.
Claims priority of provisional application 62/700,596, filed on Jul. 19, 2018.
Prior Publication US 2022/0306758 A1, Sep. 29, 2022
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); C07K 16/46 (2006.01); A61P 35/00 (2006.01)
CPC C07K 16/2878 (2013.01) [A61K 39/4611 (2023.05); A61K 39/464417 (2023.05); A61K 39/464429 (2023.05); C07K 16/2809 (2013.01); C07K 16/468 (2013.01); A61K 2239/31 (2023.05); A61K 2239/38 (2023.05); A61K 2239/48 (2023.05); A61P 35/00 (2018.01); C07K 2317/31 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A group of nucleic acid molecules encoding a bispecific antigen-binding molecule that binds human B cell maturation antigen (BCMA) and human CD3, wherein the group of nucleic acid molecules comprises:
(a) a first nucleic acid molecule encoding a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO: 66, wherein the first nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO: 65;
(b) a second nucleic acid molecule encoding a HCVR comprising the amino acid sequence of SEQ ID NO: 90, wherein the second nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO: 89; and
(c) a third nucleic acid molecule encoding a common light chain variable region (LCVR) comprising the amino acid sequence of SEQ ID NO: 82, wherein the third nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO: 81.