CPC C07K 16/283 (2013.01) [C07K 16/246 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C07K 16/40 (2013.01); C07K 16/4283 (2013.01); C12N 15/85 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/32 (2013.01); C07K 2317/55 (2013.01); C07K 2317/567 (2013.01); C07K 2317/622 (2013.01); C07K 2317/732 (2013.01); C07K 2317/75 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] | 76 Claims |
1. An isolated nucleic acid comprising a nucleic acid sequence encoding an antibody that binds to human SIRPA, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises: an HVR-H1 comprising the amino acid sequence of SEQ ID NO:20; an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 21; an HVR-H3 comprising an amino acid sequence selected from SEQ ID NOs: 22, 23, and 24; and the light chain variable region comprises: an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 9; an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 10; and an HVR-L3 comprising an amino acid sequence selected from SEQ ID NOs: 11, 12, 13, 14, 15, 16, 17, 18, and 19.
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