US 12,258,410 B2
Anti-SIRPα antibodies and methods of use thereof
Andrew Pincetic, San Francisco, CA (US); Wei-Hsien Ho, Belmont, CA (US); Patricia Culp, Oakland, CA (US); and Arnon Rosenthal, Woodside, CA (US)
Assigned to Alector LLC
Filed by Alector LLC, South San Francisco, CA (US)
Filed on Apr. 5, 2024, as Appl. No. 18/627,754.
Application 18/627,754 is a division of application No. 17/707,637, filed on Mar. 29, 2022, granted, now 11,976,119.
Application 17/707,637 is a division of application No. 16/421,692, filed on May 24, 2019, granted, now 11,319,373, issued on May 3, 2022.
Claims priority of provisional application 62/676,813, filed on May 25, 2018.
Prior Publication US 2024/0301071 A1, Sep. 12, 2024
Int. Cl. C07K 16/28 (2006.01); C07K 16/24 (2006.01); C07K 16/40 (2006.01); C07K 16/42 (2006.01); C12N 15/85 (2006.01)
CPC C07K 16/283 (2013.01) [C07K 16/246 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); C07K 16/40 (2013.01); C07K 16/4283 (2013.01); C12N 15/85 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/32 (2013.01); C07K 2317/55 (2013.01); C07K 2317/567 (2013.01); C07K 2317/622 (2013.01); C07K 2317/732 (2013.01); C07K 2317/75 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 76 Claims
 
1. An isolated nucleic acid comprising a nucleic acid sequence encoding an antibody that binds to human SIRPA, wherein the antibody comprises a heavy chain variable region and a light chain variable region, wherein the heavy chain variable region comprises: an HVR-H1 comprising the amino acid sequence of SEQ ID NO:20; an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 21; an HVR-H3 comprising an amino acid sequence selected from SEQ ID NOs: 22, 23, and 24; and the light chain variable region comprises: an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 9; an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 10; and an HVR-L3 comprising an amino acid sequence selected from SEQ ID NOs: 11, 12, 13, 14, 15, 16, 17, 18, and 19.