US 12,258,404 B2
Bispecific antibody construct directed to MUC17 and CD3
Tobias Raum, Munich (DE); Tara Arvedson, Thousand Oaks, CA (US); Julie Bailis, Thousand Oaks, CA (US); Christoph Dahlhoff, Munich (DE); Sandra Ross, Thousand Oaks, CA (US); Irwin Chen, Thousand Oaks, CA (US); Claudia Blümel, Munich (DE); Elisabeth Nahrwold, Munich (DE); Jochen Pendzialek, Munich (DE); and Joachim Wahl, Munich (DE)
Assigned to AMGEN INC., Thousand Oaks, CA (US); and AMGEN RESEARCH (MUNICH) GMBH, Munich (DE)
Appl. No. 16/956,797
Filed by AMGEN INC., Thousand Oaks, CA (US); and AMGEN RESEARCH (MUNICH) GMBH, Munich (DE)
PCT Filed Dec. 31, 2018, PCT No. PCT/US2018/068118
§ 371(c)(1), (2) Date Jun. 22, 2020,
PCT Pub. No. WO2019/133961, PCT Pub. Date Jul. 4, 2019.
Claims priority of provisional application 62/687,063, filed on Jun. 19, 2018.
Claims priority of provisional application 62/612,242, filed on Dec. 29, 2017.
Prior Publication US 2021/0130465 A1, May 6, 2021
Int. Cl. C07K 16/00 (2006.01); A61K 9/00 (2006.01); A61P 35/00 (2006.01); C07K 16/28 (2006.01); C07K 16/30 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/2809 (2013.01) [A61K 9/0019 (2013.01); A61P 35/00 (2018.01); C07K 16/3092 (2013.01); A61K 2039/505 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); A61K 2039/572 (2013.01); C07K 2317/31 (2013.01); C07K 2317/33 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/53 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01)] 19 Claims
 
1. A bispecific antibody construct comprising:
a first domain comprising an antibody which binds to MUC17, wherein the antibody comprises a CDR-H1 as set forth in the amino acid sequence of SEQ ID NO: 176, a CDR-H2 as set forth in the amino acid sequence of SEQ ID NO: 177, a CDR-H3 as set forth in the amino acid sequence of SEQ ID NO: 178, a CDR-L1 as set forth in in the amino acid sequence of SEQ ID NO: 179, a CDR-L2 as set forth in the amino acid sequence of SEQ ID NO: 180, and a CDR-L3 as set forth in the amino acid sequence of SEQ ID NO: 181, and
a second domain comprising an antibody which binds to an extracellular epitope of the human CD3ε chain.