US 12,258,379 B2
Compositions and methods for switchable CAR T cells using surface-bound sortase transpeptidase
Mauro Castellarin, Ardmore, PA (US); and June Carl, Merion Station, PA (US)
Assigned to The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Appl. No. 17/284,407
Filed by THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, Philadelphia, PA (US)
PCT Filed Oct. 12, 2019, PCT No. PCT/US2019/056011
§ 371(c)(1), (2) Date Apr. 9, 2021,
PCT Pub. No. WO2020/077318, PCT Pub. Date Apr. 16, 2020.
Claims priority of provisional application 62/745,105, filed on Oct. 12, 2018.
Prior Publication US 2021/0347845 A1, Nov. 11, 2021
Int. Cl. C07K 14/705 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 16/32 (2006.01); C12N 9/52 (2006.01)
CPC C07K 14/705 (2013.01) [A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/464404 (2023.05); A61K 39/464406 (2023.05); A61K 39/464468 (2023.05); A61P 35/00 (2018.01); C07K 16/32 (2013.01); C12N 9/52 (2013.01); A61K 38/00 (2013.01); A61K 2239/23 (2023.05); A61K 2239/31 (2023.05); C12Y 304/2207 (2013.01)] 15 Claims
 
1. A sortase immune receptor comprising, from N-terminus to C-terminus:
a sortase enzymatic region;
a transmembrane domain; and
an intracellular domain.