US 12,258,370 B2
Betulastatin compounds
George R. Pettit, Paradise Valley, AZ (US); and Noeleen Melody, Mesa, AZ (US)
Assigned to Arizona Board of Regents on behalf of Arizona State University, Scottsdale, AZ (US)
Filed by Arizona Board of Regents on behalf of Arizona State University, Scottsdale, AZ (US)
Filed on Feb. 8, 2023, as Appl. No. 18/166,008.
Application 18/166,008 is a continuation of application No. 16/762,781, granted, now 11,629,167, previously published as PCT/US2018/060015, filed on Nov. 9, 2018.
Claims priority of provisional application 62/584,051, filed on Nov. 9, 2017.
Prior Publication US 2023/0192759 A1, Jun. 22, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07J 63/00 (2006.01); A61P 35/00 (2006.01); C07J 71/00 (2006.01)
CPC C07J 63/008 (2013.01) [A61P 35/00 (2018.01); C07J 71/0052 (2013.01)] 16 Claims
 
1. A compound of formula (II)

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof, wherein
R1 is OH, OCOCH3, O—P(═O)OR′OR″, or O-Protecting Group, wherein R′ and R″ are independently selected from the group consisting of lithium (Li+), sodium (Na+), potassium (K+), hydrogen (H), morpholine, quinine, tris(hydroxymethyl)aminomethane (TRIS), serine, and nitroarginine;
R3 is R4 or R6-R4;
R4 is

OG Complex Work Unit Chemistry
R5 is H or (C1-C6)alkyl; and
R6 is (C1-C6)alkyl.