	US 12,258,336 B2
	Preparation of seimicarbazide-sensitive amine oxidase inhibitor and use thereof
Shengyang Liu, Shanghai (CN); Jianwen Deng, Shanghai (CN); Zhiyong Feng, Shanghai (CN); Lei Jiang, Shanghai (CN); Zhi Qiao, Shanghai (CN); Ke Shang, Shanghai (CN); Xiaoping Xie, Shanghai (CN); Xueli Xu, Shanghai (CN); Yuan Xu, Shanghai (CN); and Haixia Zhao, Shanghai (CN)
Assigned to SHANGHAI ENNOVABIO PHARMACEUTICALS CO., LTD., Shanghai (CN)
Appl. No. 17/279,394
Filed by SHANGHAI ENNOVABIO PHARMACEUTICALS CO., LTD., Shanghai (CN)
PCT Filed Sep. 25, 2019, PCT No. PCT/CN2019/107972 § 371(c)(1), (2) Date Mar. 24, 2021, PCT Pub. No. WO2020/063696, PCT Pub. Date Apr. 2, 2020.
Claims priority of application No. 201811119234.2 (CN), filed on Sep. 25, 2018.
Prior Publication US 2022/0081426 A1, Mar. 17, 2022
Int. Cl. C07D 407/14 (2006.01); C07D 401/04 (2006.01); C07D 471/08 (2006.01); C07D 487/08 (2006.01); C07D 491/107 (2006.01)

CPC C07D 407/14 (2013.01) [C07D 401/04 (2013.01); C07D 471/08 (2013.01); C07D 487/08 (2013.01); C07D 491/107 (2013.01)]

10 Claims

1. A compound according to Formula I, or stereoisomers or racemates thereof, or pharmaceutically acceptable salts thereof:

wherein,

A is none;

B is substituted or unsubstituted 6 membered heteroaromatic ring; wherein the heteroaromatic ring contains 1-2 nitrogen atoms;

L₁is —O—;

L₂is none;

L₃is a substituted or unsubstituted 5-12 membered heterocyclic ring, the heterocyclic ring contains 1-3 heteroatoms selected from nitrogen, oxygen or sulfur;

R₁is F, and R₂is H; or R₁is H, and R₂is F;

R₃and R₄are H;

R₅and R₆are each independently a hydrogen;

R₇is a 4-6 membered heterocyclic ring containing 1 oxygen atom;

R₈is selected from the group consisting of H, and —CN;

R₈′ is none;

X is —CR₁₁R₁₂; and

R₁₁and R₁₂are each independently H;

with the proviso that the above groups constitute a chemically stable structure;

wherein unless otherwise specified, the above-mentioned “substituted” means one or more hydrogen atoms on the group being substituted by C₁-C₆alkyl.