US 12,258,305 B2
Alcohol derivatives as Kv7 potassium channel openers
Mario Rottlander, Greve (DK); Anette Graven Sams, Vaerlose (DK); Xiaofang Wang, Shanghai (CN); Debasis Das, Shanghai (CN); Jian Hong, Shanghai (CN); and Shu Hui Chen, Calabasas, CA (US)
Assigned to H. Lundbeck A/S, Valby (DK)
Filed by H. Lundbeck A/S, Valby (DK)
Filed on Jul. 20, 2022, as Appl. No. 17/869,116.
Application 16/781,106 is a division of application No. 15/899,843, filed on Feb. 20, 2018, granted, now 10,590,067.
Application 17/869,116 is a continuation of application No. 16/781,106, filed on Feb. 4, 2020, granted, now 11,434,199.
Prior Publication US 2022/0380300 A1, Dec. 1, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61P 25/08 (2006.01); A61P 25/04 (2006.01); A61P 25/06 (2006.01); A61P 25/18 (2006.01); A61P 25/22 (2006.01); A61P 25/24 (2006.01); A61P 25/28 (2006.01); C07C 235/06 (2006.01); C07C 235/08 (2006.01); C07C 235/26 (2006.01)
CPC C07C 235/06 (2013.01) [A61P 25/04 (2018.01); A61P 25/06 (2018.01); A61P 25/08 (2018.01); A61P 25/18 (2018.01); A61P 25/22 (2018.01); A61P 25/24 (2018.01); A61P 25/28 (2018.01); C07C 235/08 (2013.01); C07C 235/26 (2013.01); C07B 2200/07 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05)] 20 Claims
 
1. A method of treating a patient in the need thereof suffering from mania, acute stress reactions, bipolar depression, major depression, anxiety, panic attacks, social phobia, chronic pain, neuropathy, autism spectrum disorders, Huntington's chorea, or sclerosis, comprising administering to the patient a therapeutically effective amount of a compound of Formula (I):

OG Complex Work Unit Chemistry
wherein
R1 is selected from the group consisting of C1-C6 alkyl, CF3, CH2CF3, CF2CHF2, and C3-C8 cycloalkyl, wherein said C3-C8 cycloalkyl may be substituted with 1 or 2 F, CHF2 or CF3, and
R2 is H, C1-C6 alkyl or CF3;
or
R1 and R2 combine to form C3-C5 cycloalkyl optionally substituted with 1 or 2 F, CHF2 or CF3;
R3 is C1-C3 alkyl or CH2O—C1-3 alkyl, wherein said C1-C3 alkyl or CH2O—C1-3 alkyl may be optionally substituted with 1 or 2 F; and
R4 is selected from the group consisting of CF3, OCF3, OCH2CF3 and OCHF2.