US 12,257,457 B2
Neuromodulation techniques for perturbation of physiological systems
Christopher Michael Puleo, Niskayuna, NY (US); Victoria Eugenia Cotero, Troy, NY (US); Jeffrey Michael Ashe, Gloversville, NY (US); and John Frederick Graf, Ballston Lake, NY (US)
Assigned to GENERAL ELECTRIC COMPANY, Schenectady, NY (US)
Filed by General Electric Company, Schenectady, NY (US)
Filed on Jul. 13, 2022, as Appl. No. 17/864,212.
Application 17/864,212 is a division of application No. 16/399,692, filed on Apr. 30, 2019, granted, now 11,426,610.
Prior Publication US 2022/0362587 A1, Nov. 17, 2022
Int. Cl. A61N 7/00 (2006.01); A61N 1/05 (2006.01); A61N 1/36 (2006.01)
CPC A61N 7/00 (2013.01) [A61N 1/0536 (2013.01); A61N 1/36017 (2013.01); A61N 2007/0026 (2013.01); A61N 2007/0073 (2013.01); A61N 2007/0078 (2013.01)] 16 Claims
OG exemplary drawing
 
12. A method of causing a change in concentration of one or more molecules in a subject, the method comprising:
directing energy of an energy application device at a region of interest of a subject, wherein the energy application device delivers treatment energy to the region of interest and wherein the treatment energy is applied according to a treatment protocol based on a circulating glucose concentration;
applying the energy to the region of interest to cause the change in concentration of the one or more molecules as a result of applying the energy;
assessing the change in concentration of the one or more molecules relative to a baseline concentration of the one or more molecules at one or more time points after applying the energy; and
determining, based on the assessing, that the subject is in a category selected from a first category or a second category, wherein the first category is responsive to neuromodulation and the second category is non-responsive to neuromodulation and the subject is determined to be in the second category when a change in the concentration relative to the baseline concentration is less than a predetermined threshold change.