| CPC A61N 5/103 (2013.01) [A61N 5/1045 (2013.01); A61N 5/1067 (2013.01); A61N 5/107 (2013.01); A61N 5/1081 (2013.01); A61N 2005/1074 (2013.01)] | 23 Claims |

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1. A radiotherapy device comprising:
a radiation source configured to apply radiation to a treatment region coinciding with a subject according to a treatment plan;
one or more imaging systems configured to generate image data of the subject; and
a controller communicatively coupled to the radiation source and to the one or more imaging systems, the controller being configured to:
determine, based on the image data, a relative distance between a target region of the subject and an organ at risk of the subject, wherein the treatment plan comprises a prescribed dose for the target region;
determine a buffer region around the target region based at least in part on the relative distance; and
generate a control signal for adjusting a radiotherapy treatment in response to determining, based on the image data, that the treatment region is located at least partially outside the buffer region.
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