US 12,257,432 B2
Implantable and non-invasive stimulators for gastrointestinal therapeutics
Yi-Kai Lo, Los Angeles, CA (US); and Wentai Liu, Los Angeles, CA (US)
Assigned to THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed by THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US)
Filed on Nov. 1, 2023, as Appl. No. 18/499,304.
Application 17/525,827 is a division of application No. 16/437,359, filed on Jun. 11, 2019, granted, now 11,202,907, issued on Dec. 21, 2021.
Application 18/499,304 is a division of application No. 16/437,359, filed on Jun. 11, 2019, granted, now 11,202,907, issued on Dec. 21, 2021.
Application 18/499,304 is a continuation of application No. 17/525,827, filed on Nov. 12, 2021, granted, now 11,857,783.
Application 16/437,359 is a continuation of application No. PCT/US2017/065917, filed on Dec. 12, 2017.
Application 16/437,359 is a continuation of application No. PCT/US2017/065917, filed on Dec. 12, 2017.
Claims priority of provisional application 62/433,122, filed on Dec. 12, 2016.
Prior Publication US 2024/0131329 A1, Apr. 25, 2024
Prior Publication US 2024/0226549 A9, Jul. 11, 2024
Int. Cl. A61N 1/36 (2006.01); A61N 1/05 (2006.01); A61N 1/372 (2006.01); A61N 1/375 (2006.01)
CPC A61N 1/36007 (2013.01) [A61N 1/0509 (2013.01); A61N 1/36139 (2013.01); A61N 1/36167 (2013.01); A61N 1/37229 (2013.01); A61N 1/37235 (2013.01); A61N 1/37518 (2017.08)] 19 Claims
OG exemplary drawing
 
1. A method comprising:
installing an apparatus at a treatment location of a gastrointestinal (GI) tract of a patient, wherein the apparatus comprises a plurality of electrodes;
configuring, by a processor associated with the apparatus, a high intensity GI stimulation according to a user definition;
inserting, by the processor, a low intensity recording pulse within the GI stimulation;
delivering, by at least one of the plurality of electrodes selected according to the user definition, a waveform, comprising the GI stimulation and the recording pulse, to the treatment location;
determining, by the processor, a GI motility indicator based on the recording pulse; and
adjusting, by the processor, at least one parameter of the GI stimulation based on the GI motility indicator;
wherein the GI stimulation aims to restore GI motility and/or reduce inflammatory responses.