US 12,257,417 B2
Devices and methods for providing a bolus dose in a microfluidic circuit of a pump
Hermanus Stephanus Pretorius, Derry, NH (US); Robert Farra, Acton, MA (US); Kenneth Barnett, Waltham, MA (US); David Piper, Leominster, MA (US); Russell Ford, Palo Alto, CA (US); Edward G. Solomon, Menlo Park, CA (US); Peter Holst, Los Altos, CA (US); and Lawrence Smith, Boulder, CO (US)
Assigned to CEQUR SA, Horw (CH)
Filed by Cequr SA, Horw (CH)
Filed on Apr. 15, 2021, as Appl. No. 17/231,075.
Application 17/231,075 is a continuation of application No. 16/401,178, filed on May 2, 2019, granted, now 11,007,317.
Claims priority of provisional application 62/665,825, filed on May 2, 2018.
Prior Publication US 2021/0228801 A1, Jul. 29, 2021
Int. Cl. A61M 5/168 (2006.01); A61B 5/00 (2006.01); A61M 5/142 (2006.01); A61M 5/145 (2006.01)
CPC A61M 5/16804 (2013.01) [A61B 5/4839 (2013.01); A61M 5/16881 (2013.01); A61M 5/1424 (2013.01); A61M 5/14248 (2013.01); A61M 2005/14506 (2013.01); A61M 5/16809 (2013.01); A61M 5/16854 (2013.01); A61M 2205/502 (2013.01); A61M 2205/7545 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A device for administering a medication in fluid form, the device comprising:
a basal flow path; and
a bolus flow path in parallel to the basal flow path, wherein the bolus flow path comprises a combined piston pump and rotatable valve, wherein the combined piston pump and rotatable valve comprises:
a base comprising an inlet and an outlet;
a rotatable valve body rotatably disposed about the base;
a bolus chamber formed within the rotatable valve body, wherein the bolus chamber comprises an inlet and an outlet;
a moveable and rotatable piston at least partially disposed within the bolus chamber and in mechanical communication with the rotatable valve body, wherein the moveable and rotatable piston comprises a first position and a second position;
a spring disposed about the moveable and rotatable piston, wherein the spring biases the moveable and rotatable piston in the first position;
an inlet seal disposed about the base to form a fill pocket about the inlet of the bolus chamber;
an outlet seal disposed about the base to form a dose pocket about the outlet of the bolus chamber; and
a vent disposed in the base,
wherein as the moveable and rotatable piston moves between the first position and the second position, the inlet and/or outlet of the bolus chamber is located between the fill pocket and the dose pocket such that medicament released into a void between the rotatable valve body and the base is vented via the vent to a location outside of the combined piston pump and rotatable valve and away from a patient.
 
12. A device for administering a bolus dose of a medication to a patient, the device comprising:
a bolus flow path; and
a combined piston pump and rotatable valve disposed along the bolus flow path and configured to prevent partial dosing of a bolus dose, wherein the combined piston pump and rotatable valve comprises
a base comprising an inlet and an outlet:
a rotatable valve body rotatably disposed about the base:
a bolus chamber formed within the rotatable valve body, wherein the bolus chamber comprises an inlet and an outlet:
a moveable and rotatable piston at least partially disposed within the bolus chamber and in mechanical communication with the rotatable valve body, wherein the moveable and rotatable piston comprises a first position and a second position;
a spring disposed about the moveable and rotatable piston, wherein the spring biases the moveable and rotatable piston in the first position;
an inlet seal disposed about the base to form a fill pocket about the inlet of the bolus chamber;
an outlet seal disposed about the base to form a dose pocket about the outlet of the bolus chamber; and
a vent disposed in the base,
wherein as the moveable and rotatable piston moves between the first position and the second position, the inlet and/or outlet of the bolus chamber is located between the fill pocket and the dose pocket such that medicament released into a void between the rotatable valve body and the base is vented via the vent to a location outside of the combined piston pump and rotatable valve and away from a patient.