US 12,257,391 B2
Systems and methods for manufacturing and safety of an NO2-to-NO reactor cartridge used to deliver no for inhalation therapy to a patient
Jaron M. Acker, Madison, WI (US); and Thomas Kohlmann, McFarland, WI (US)
Assigned to Mallinckrodt Pharmaceuticals Ireland Limited, Dublin (IE)
Filed by Mallinckrodt Pharmaceuticals Ireland Limited, Dublin (IE)
Filed on Dec. 19, 2022, as Appl. No. 18/084,113.
Application 18/084,113 is a division of application No. 16/502,828, filed on Jul. 3, 2019, granted, now 11,554,242.
Application 16/502,828 is a division of application No. 14/744,298, filed on Jun. 19, 2015, granted, now 10,384,031, issued on Aug. 20, 2019.
Claims priority of provisional application 62/015,088, filed on Jun. 20, 2014.
Prior Publication US 2023/0124997 A1, Apr. 20, 2023
Int. Cl. A61M 16/12 (2006.01); A61M 16/00 (2006.01); A61M 16/08 (2006.01); A61M 16/20 (2006.01); B01J 8/02 (2006.01); G01F 1/34 (2006.01)
CPC A61M 16/122 (2014.02) [A61M 16/0003 (2014.02); A61M 16/0051 (2013.01); A61M 16/0875 (2013.01); A61M 16/20 (2013.01); B01J 8/02 (2013.01); G01F 1/34 (2013.01); A61M 2016/003 (2013.01); A61M 2202/0275 (2013.01); A61M 2205/18 (2013.01); A61M 2205/3334 (2013.01); A61M 2205/35 (2013.01); A61M 2205/50 (2013.01); B01J 2208/00893 (2013.01); B01J 2208/02 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A method of testing reactor cartridges to determine an expected lifetime, comprising:
assembling a number of reactor cartridges, comprising;
providing a plurality of conversion cartridge shells;
placing a first retainer on a support within the shell to partition off a section of the internal space;
introducing a volume of a consumable conversion media into at least a portion of the internal volume of the conversion cartridge;
placing a second retainer within the shell, that is held in position against the volume of consumable conversion media by a force-applying member;
closing an inlet end of the conversion cartridge shell with an inlet end wall,
wherein an end of the force-applying member is in contact with the inlet end wall and an opposite end of the force-applying member is in contact with the second retainer, so that a force is applied to the volume of a consumable conversion media; and
closing an outlet end of the conversion cartridge shell with an outlet end wall;
randomly selecting a number of reactor cartridges from the plurality of assembled reactor cartridges, where the number of cartridges selected for testing is less than the number of cartridges assembled;
installing a randomly selected reactor cartridge into a NO gas delivery system;
testing the installed reactor cartridge by a process comprising:
flowing a gas containing a predetermined concentration of NO2 through the installed reactor cartridge;
measuring the amount of NO2-containing gas fed into the reactor cartridge with a flow meter;
detecting the presence of NO2 at the outlet of the reactor cartridge; and
calculating the amount of NO2 converted to NO by the reactor cartridge up to the time NO2 was detected at the outlet of the of the reactor cartridge with a computer; and
replacing the installed reactor cartridge with a subsequent randomly selected cartridge and repeating the testing process until all randomly selected reactor cartridges have been tested.