US 12,257,371 B2
SiOx barrier for pharmaceutical package and coating process
Christopher Weikart, Auburn, AL (US); John T. Felts, Alameda, CA (US); Thomas E. Fisk, Green Valley, AZ (US); Robert S. Abrams, Albany, NY (US); John Ferguson, Auburn, AL (US); Jonathan R. Freedman, Auburn, AL (US); Robert J. Pangborn, Harbor Springs, MI (US); and Peter J. Sagona, Pottstown, PA (US)
Assigned to SIO2 MEDICAL PRODUCTS, LLC, Auburn, AL (US)
Filed by SiO2 Medical Products, Inc., Auburn, AL (US)
Filed on May 3, 2021, as Appl. No. 17/306,621.
Application 17/306,621 is a continuation of application No. 14/412,472, abandoned, previously published as PCT/US2013/048709, filed on Jun. 28, 2013.
Claims priority of provisional application 61/800,494, filed on Mar. 15, 2013.
Claims priority of provisional application 61/792,952, filed on Mar. 15, 2013.
Claims priority of provisional application 61/800,746, filed on Mar. 15, 2013.
Claims priority of provisional application 61/800,660, filed on Mar. 15, 2013.
Claims priority of provisional application 61/776,733, filed on Mar. 11, 2013.
Claims priority of provisional application 61/771,644, filed on Mar. 1, 2013.
Claims priority of provisional application 61/747,584, filed on Dec. 31, 2012.
Claims priority of provisional application 61/732,180, filed on Nov. 30, 2012.
Claims priority of provisional application 61/713,435, filed on Oct. 12, 2012.
Prior Publication US 2021/0330869 A1, Oct. 28, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 31/08 (2006.01); A61F 9/00 (2006.01); A61J 1/03 (2023.01); A61J 1/05 (2006.01); A61J 1/14 (2023.01); A61L 29/10 (2006.01); A61M 5/31 (2006.01); A61M 15/00 (2006.01); C23C 16/40 (2006.01)
CPC A61L 31/088 (2013.01) [A61J 1/035 (2013.01); A61J 1/05 (2013.01); A61L 29/106 (2013.01); A61M 5/3129 (2013.01); C23C 16/401 (2013.01); A61F 9/0008 (2013.01); A61J 1/1468 (2015.05); A61L 2420/02 (2013.01); A61M 15/0001 (2014.02); A61M 2202/048 (2013.01); A61M 2205/0238 (2013.01); A61M 2205/19 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A vessel comprising a thermoplastic wall enclosing a lumen and an SiOx composite barrier coating or layer, for which x is from 1.8 to 2.4, supported by the wall between the wall and the lumen, an interior surface of the composite barrier coating or layer facing the lumen, and
a pH protective coating or layer of SiOxCy or SiNxCy wherein x is from about 0.5 to about 2.4 and y is from about 0.6 and about 3, the pH protective coating or layer having an interior surface facing the lumen and an outer surface facing the interior surface of the composite barrier coating or layer,
in which an FTIR absorbance spectrum of the pH protective coating or layer has a ratio greater than 0.75 and at most 1 between:
the maximum amplitude of the Si—O—Si symmetrical stretch peak between about 1000 and 1040 cm−1, and
the maximum amplitude of the Si—O—Si asymmetric stretch peak between about 1060 and about 1100 cm−1,
the pH protective coating or layer being effective to increase the calculated shelf life of the vessel (total Si/Si dissolution rate).