US 12,257,370 B2
Coatings for medical devices
Gregory M. Cruise, Rancho Santa Margarita, CA (US); Steve Plotkin, Beaumont, CA (US); and Petr Vasek, Costa Mesa, CA (US)
Assigned to MicroVention, Inc., Aliso Viejo, CA (US)
Filed by MicroVention, Inc., Aliso Viejo, CA (US)
Filed on Jul. 24, 2020, as Appl. No. 16/938,571.
Claims priority of provisional application 62/879,287, filed on Jul. 26, 2019.
Prior Publication US 2021/0023276 A1, Jan. 28, 2021
Int. Cl. A61L 29/08 (2006.01); A61L 29/04 (2006.01); A61M 25/00 (2006.01); A61B 5/15 (2006.01)
CPC A61L 29/085 (2013.01) [A61L 29/049 (2013.01); A61B 5/150992 (2013.01); A61L 2400/10 (2013.01); A61M 25/0045 (2013.01)] 7 Claims
 
1. A coated medical device comprising:
a base coat including a copolymer of tetrahydrofurfuryl acrylate and 4-hydroxybutyl acrylate; and
a top coat polymer containing more than two reactive moieties per molecule, wherein the top coat includes a hemocompatible copolymer of a first component and a second component,
wherein the first component is selected from

OG Complex Work Unit Chemistry
a (meth)acrylate monomer comprising a diazeniumdiolate or S-nitrosothiol moiety, a hydrophilic monomer, or methoxyethyl acrylate,
wherein the hydrophilic monomer includes an acrylamide, vinyl alcohol, n-vinyl pyrrolidone, hydroxyethyl methacrylate, or poly(ethylene glycol) moiety.