US 12,257,366 B2
Hybrid scaffold suitable for regenerating animal tissues and process for producing the scaffold
Francesco Giovanni Greco, Cantu (IT); Stefania Adele Riboldi, Milan (IT); Sebastiao Nicolau Dentinho Van Uden, Sintra (PT); Valentina Ilaria Maria Catto, Brugherio (IT); and Davide Meroni, Lissone (IT)
Assigned to DIALYBRID S.R.L., Cantu (IT)
Filed by Dialybrid S.r.l., Cantu CO (IT)
Filed on Aug. 9, 2021, as Appl. No. 17/397,365.
Application 17/397,365 is a division of application No. 16/394,662, filed on Apr. 25, 2019, granted, now 11,213,612.
Application 16/394,662 is a continuation in part of application No. PCT/EP2017/001263, filed on Oct. 27, 2017.
Claims priority of application No. 16425100 (EP), filed on Oct. 28, 2016.
Prior Publication US 2021/0361831 A1, Nov. 25, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 27/50 (2006.01); A61F 2/24 (2006.01); A61L 27/04 (2006.01); A61L 27/22 (2006.01); A61L 27/26 (2006.01); A61L 27/34 (2006.01); A61L 27/36 (2006.01); A61L 27/48 (2006.01); A61L 33/18 (2006.01); A61M 1/36 (2006.01); D01D 5/00 (2006.01); D01D 5/34 (2006.01); A61F 2/06 (2013.01)
CPC A61L 27/507 (2013.01) [A61F 2/24 (2013.01); A61L 27/047 (2013.01); A61L 27/227 (2013.01); A61L 27/26 (2013.01); A61L 27/34 (2013.01); A61L 27/3687 (2013.01); A61L 27/48 (2013.01); A61L 33/18 (2013.01); A61M 1/3655 (2013.01); D01D 5/003 (2013.01); D01D 5/34 (2013.01); A61F 2002/065 (2013.01); A61F 2240/001 (2013.01); A61L 2420/02 (2013.01); A61L 2420/06 (2013.01); A61L 2430/20 (2013.01); D10B 2211/22 (2013.01); D10B 2331/10 (2013.01); D10B 2509/06 (2013.01)] 15 Claims
 
1. A method of producing a mixture of fibroin and polyurethane, the method comprising the following steps:
dissolving fibroin in formic acid obtaining a first solution of fibroin;
dissolving polyurethane into a combination of formic acid and dichloromethane obtaining a second solution of polyurethane dissolved in formic acid and dichloromethane;
mixing the first solution with the second solution together thereby obtaining the mixture of fibroin and polyurethane dissolved in a final combination of formic acid and dichloromethane while avoiding precipitation in the mixture.