US 12,257,365 B2
Incised Descemet's membrane and methods of making and using
Joshua Honghan Hou, Minneapolis, MN (US); Peter Bedard, St. Paul, MN (US); Jeffrey Joseph Justin, St. Paul, MN (US); Mark Spencer Hansen, Long Lake, MN (US); Martin de la Presa, Roseville, MN (US); and David Ronald Hardten, Excelsior, MN (US)
Assigned to REGENTS OF THE UNIVERSITY OF MINNESOTA, Minneapolis, MN (US)
Filed by Regents of the University of Minnesota, Minneapolis, MN (US)
Filed on Apr. 24, 2020, as Appl. No. 16/858,299.
Claims priority of provisional application 62/838,986, filed on Apr. 26, 2019.
Prior Publication US 2020/0338235 A1, Oct. 29, 2020
Int. Cl. A61L 27/38 (2006.01); A61F 2/14 (2006.01); A61L 27/36 (2006.01)
CPC A61L 27/3839 (2013.01) [A61F 2/142 (2013.01); A61L 27/3691 (2013.01); A61L 27/3808 (2013.01); A61L 27/3886 (2013.01); A61F 2/148 (2013.01); A61F 2230/0023 (2013.01); A61F 2250/0097 (2013.01); A61L 2300/442 (2013.01); A61L 2400/18 (2013.01); A61L 2430/16 (2013.01)] 37 Claims
OG exemplary drawing
 
1. A composition for corneal transplantation comprising:
a Descemet's Membrane Endothelial Keratoplasty (DMEK) graft comprising two incisions, three scrolling axes, and a triple scroll conformation;
wherein the DMEK graft comprises Descemet's membrane and corneal endothelial cells;
wherein the DMEK graft has a geometric center; and
wherein the two incisions are placed at a distance apart from each other in a range of 105 degrees to 135 degrees, the distance between the incisions being measured relative to the geometric center of the DMEK graft.