US 12,257,363 B2
Medical device for neural repairing of the spinal cord or of a nerve
Michele Conti, Nogaredo (IT)
Assigned to Michele Conti, Nogaredo (IT)
Appl. No. 17/269,237
Filed by Michele Conti, Nogaredo (IT)
PCT Filed Aug. 30, 2019, PCT No. PCT/IB2019/057332
§ 371(c)(1), (2) Date Feb. 17, 2021,
PCT Pub. No. WO2020/044304, PCT Pub. Date Mar. 5, 2020.
Claims priority of application No. 102018000008253 (IT), filed on Aug. 30, 2018.
Prior Publication US 2021/0322640 A1, Oct. 21, 2021
Int. Cl. A61L 27/36 (2006.01); A61L 27/18 (2006.01); A61L 27/22 (2006.01); A61L 27/30 (2006.01); A61L 27/38 (2006.01); A61L 27/54 (2006.01)
CPC A61L 27/3675 (2013.01) [A61L 27/18 (2013.01); A61L 27/225 (2013.01); A61L 27/303 (2013.01); A61L 27/306 (2013.01); A61L 27/3612 (2013.01); A61L 27/362 (2013.01); A61L 27/3625 (2013.01); A61L 27/3834 (2013.01); A61L 27/3878 (2013.01); A61L 27/54 (2013.01); A61L 2300/414 (2013.01); A61L 2400/12 (2013.01); A61L 2420/04 (2013.01); A61L 2430/32 (2013.01)] 3 Claims
OG exemplary drawing
 
1. A method for implanting a medical device for repairing an injury to the spinal cord, the medical device comprising a first biological or biocompatible flexible substrate which supports first nanoparticles selected from the group consisting of silicon, carbon, gold, and titanium, at least partially embedded in a binding layer made of binding material, said binding layer being joined to the first biological or biocompatible flexible substrate, wherein each first nanoparticle of said first nanoparticles extends along a preferential direction of development (X) and wherein the first nanoparticles are oriented so that, statistically, said preferential direction of development (X) of each first nanoparticle is parallel to a first orientation of growth (X1), and wherein stem cells are at least partially embedded in said binding layer and said first nanoparticles are functionalized so that differentiation of said stem cells is guided along said first nanoparticles in the first orientation of growth (X1); wherein the first biological or biocompatible flexible substrate is suitable to assume a distended configuration and a wrapped configuration, and wherein, in said wrapped configuration, the first biological or biocompatible flexible substrate is wrapped around the spinal cord whereby said first orientation of growth (X1) is statistically parallel to a neuronal direction (X′) of extension of neurons of the spinal cord, said method comprising:
performing a dorsal laminectomy in the vicinity of a lesion to expose the dural sac;
opening the dural sac and exposing the spinal cord; and
inserting the medical device by sliding one end of the first biological or biocompatible flexible substrate from one side of the spinal cord towards an anterior region until it emerges from an opposite side of the spinal cord, whereby the medical device is wrapped around the spinal cord.