US 12,257,352 B2
Compositions and methods for delivery of biomacromolecule agents
James J. Moon, Ann Arbor, MI (US); Rui Kuai, Ann Arbor, MI (US); Anna A. Schwendeman, Ann Arbor, MI (US); and Jutaek Nam, Ann Arbor, MI (US)
Assigned to The Regents of the University of Michigan, Ann Arbor, MI (US)
Appl. No. 16/310,715
Filed by The Regents of the University of Michigan, Ann Arbor, MI (US)
PCT Filed Jun. 20, 2017, PCT No. PCT/US2017/038333
§ 371(c)(1), (2) Date Dec. 17, 2018,
PCT Pub. No. WO2017/223085, PCT Pub. Date Dec. 28, 2017.
Claims priority of provisional application 62/436,865, filed on Dec. 20, 2016.
Claims priority of provisional application 62/398,330, filed on Sep. 22, 2016.
Claims priority of provisional application 62/352,182, filed on Jun. 20, 2016.
Prior Publication US 2021/0106538 A1, Apr. 15, 2021
Int. Cl. A61K 48/00 (2006.01); A61K 9/127 (2006.01); A61K 9/1275 (2025.01); A61K 9/51 (2006.01); A61K 33/38 (2006.01); A61K 38/17 (2006.01); A61K 39/00 (2006.01); A61K 39/39 (2006.01); A61K 39/395 (2006.01); A61K 47/69 (2017.01); A61P 35/00 (2006.01); A61P 37/04 (2006.01); C12N 15/113 (2010.01); C12N 15/85 (2006.01)
CPC A61K 9/5123 (2013.01) [A61K 9/127 (2013.01); A61K 9/1275 (2013.01); A61K 33/38 (2013.01); A61K 38/1761 (2013.01); A61K 39/00 (2013.01); A61K 39/0011 (2013.01); A61K 39/001114 (2018.08); A61K 39/39 (2013.01); A61K 39/3955 (2013.01); A61K 47/6917 (2017.08); A61K 47/6929 (2017.08); A61P 35/00 (2018.01); A61P 37/04 (2018.01); C12N 15/1137 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55561 (2013.01); A61K 2039/55572 (2013.01); A61K 2039/70 (2013.01); C12N 2310/14 (2013.01); C12N 2310/3515 (2013.01); C12N 2320/32 (2013.01)] 5 Claims
 
1. A composition comprising a nanodisc comprising a phospholipid selected from 1,2-dimyristol-sn-glycero-3-phosphocholine (DMPC) and dipalmitoylphosphatidylcholine (DPPC), an apolipoprotein mimetic, and insulin.