US 12,257,346 B2
Oral powder mixture with small sized particles
Helle Wittorff, Vejle Ost (DK); and Christine Nøhr Pedersen, Aarhus C (DK)
Assigned to Fertin Pharma A/S, Vejle (DK)
Filed by Fertin Pharma A/S, Vejle (DK)
Filed on Apr. 30, 2021, as Appl. No. 17/245,179.
Claims priority of application No. PA202070298 (DK), filed on May 8, 2020.
Prior Publication US 2021/0346257 A1, Nov. 11, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/16 (2006.01); A61K 8/02 (2006.01); A61K 8/34 (2006.01); A61K 8/37 (2006.01); A61K 8/49 (2006.01); A61K 9/00 (2006.01); A61K 31/191 (2006.01); A61K 31/194 (2006.01); A61K 33/30 (2006.01); A61K 45/06 (2006.01); A61Q 11/00 (2006.01)
CPC A61K 9/1623 (2013.01) [A61K 8/022 (2013.01); A61K 8/0225 (2013.01); A61K 8/345 (2013.01); A61K 8/347 (2013.01); A61K 8/37 (2013.01); A61K 8/498 (2013.01); A61K 9/0053 (2013.01); A61K 31/191 (2013.01); A61K 31/194 (2013.01); A61K 33/30 (2013.01); A61K 45/06 (2013.01); A61Q 11/00 (2013.01); A61K 2800/28 (2013.01); A61K 2800/41 (2013.01); A61K 2800/412 (2013.01); A61K 2800/74 (2013.01); A61K 2800/92 (2013.01)] 30 Claims
 
1. A powder mixture for oral care benefits, the powder mixture having a Hausner ratio of 1.00 to 1.59 and comprising a population of particles and one or more active ingredients, the population of particles being administered as dry and flowable powder and including at least two types of sugar alcohol particles selected from the group consisting of i) non-directly compressible (non-DC) sugar alcohol particles that provide the population of particles with a salivation effect upon oral administration of the population of particles, ii) directly compressible (DC) sugar alcohol particles that are not granulated sugar alcohol particles and provide the population of particles with a cooling effect upon oral administration of the population of particles, and iii) granulated sugar alcohol particles, wherein:
at least one of said at least two types of sugar alcohol particles having a particle size with more than 50% of the particles being below 250 microns; and
at least one of said at least two types of sugar alcohol particles being present in an amount of at least 20% by weight of the powder mixture.