US 12,257,332 B2
Prevention of the oxidation of perfumery raw materials
Janille Marie Jumalon, Plainsboro, NJ (US); Addi Fadel, Plainsboro, NJ (US); Michael Calandra, Plainsboro, NJ (US); Ying Wang, Plainsboro, NJ (US); and Melanie Smith, Plainsboro, NJ (US)
Assigned to FIRMENICH SA, Satigny (CH)
Appl. No. 16/768,103
Filed by Firmenich SA, Satigny (CH)
PCT Filed Jan. 24, 2019, PCT No. PCT/EP2019/051758
§ 371(c)(1), (2) Date May 29, 2020,
PCT Pub. No. WO2019/145425, PCT Pub. Date Aug. 1, 2019.
Claims priority of provisional application 62/623,077, filed on Jan. 29, 2018.
Claims priority of application No. 18169940 (EP), filed on Apr. 27, 2018.
Prior Publication US 2020/0289388 A1, Sep. 17, 2020
Int. Cl. A61K 8/365 (2006.01); A61Q 13/00 (2006.01)
CPC A61K 8/365 (2013.01) [A61Q 13/00 (2013.01); A61K 2800/10 (2013.01); A61K 2800/522 (2013.01); A61K 2800/524 (2013.01)] 6 Claims
 
1. A method of reducing light-induced oxidation of a formulated perfume, wherein the formulated perfume is a hydroalcoholic solution, or a perfumery raw material, wherein the formulated perfume or the perfumery raw material comprises a dye, the dye being selected from the group consisting of Red 4, Red 33, Yellow 5, Yellow 6, and Orange 4, and wherein the reduction of the light-induced oxidation reduces a discoloration of the formulated perfume or perfumery raw material, the method comprising:
adding at least one α-oxocarboxylic acid, wherein the at least one α-oxocarboxylic acid is α-ketoglutaric acid, and at least one stabilizer, wherein the at least one stabilizer is a mixture of butyl methoxydibenzoyl methane, ethylhexyl methoxycinnamate, ethylhexyl salicylate, and tris (tetramethylhydroxypiperidinol) citrate, to the formulated perfume or the perfumery raw material in an amount sufficient to reduce the light-induced oxidation of the formulated perfume or the perfumery raw material, wherein the reduction of the light-induced oxidation reduces a discoloration of the formulated perfume or perfumery raw material.