	US 12,257,327 B2
	Compositions and methods for treatment and imaging using nanoparticles
Samuel Achilefu, St. Louis, MO (US); and Kvar Black, St. Louis, MO (US)
Assigned to Washington University, St. Louis, MO (US)
Filed by Washington University, St. Louis, MO (US)
Filed on May 13, 2021, as Appl. No. 17/319,780.
Application 17/319,780 is a continuation of application No. 15/959,982, filed on Apr. 23, 2018, granted, now 11,007,286.
Application 15/959,982 is a continuation of application No. 14/734,761, filed on Jun. 9, 2015, granted, now 9,974,870, issued on May 22, 2018.
Claims priority of provisional application 62/137,628, filed on Mar. 24, 2015.
Claims priority of provisional application 62/009,481, filed on Jun. 9, 2014.
Prior Publication US 2021/0386875 A1, Dec. 16, 2021
Int. Cl. A61K 51/08 (2006.01); A61K 51/12 (2006.01)

CPC A61K 51/088 (2013.01) [A61K 51/1251 (2013.01)]

18 Claims

1. A composition comprising:

(a) a peptide comprising a Tyr residue, a Cys residue, and a Matrix metallopeptidase 9 (MMP9)-sensitive site, wherein the peptide comprises the amino acid sequence set forth in SEQ ID NO: 1;

(b) a chelator coupled to the peptide; and

(c) a first radionuclide and a second radionuclide, wherein the first radionuclide is ¹²⁵I and second radionuclide is one of ¹¹¹In and ⁶⁴Cu, wherein the radionuclides are attached or coupled at positions on the peptide separated by the MMP9-sensitive site.