US 12,257,325 B2
Chelating platform for delivery of radionuclides
Roland K. Strong, Seattle, WA (US); Peter Rupert, Seattle, WA (US); Rebecca J. Abergel, Berkeley, CA (US); Ilya Captain, Moraga, CA (US); and Gauthier J P Deblonde, Berkeley, CA (US)
Assigned to Fred Hutchinson Cancer Research Center, Seattle, WA (US); and The Regents of the University of California, Oakland, CA (US)
Filed by Fred Hutchinson Cancer Research Center, Seattle, WA (US); and The Regents of the University of California, Oakland, CA (US)
Filed on Dec. 10, 2021, as Appl. No. 17/643,734.
Application 17/643,734 is a division of application No. 16/329,178, granted, now 11,235,076, previously published as PCT/US2017/048954, filed on Aug. 28, 2017.
Claims priority of provisional application 62/505,458, filed on May 12, 2017.
Claims priority of provisional application 62/401,687, filed on Sep. 29, 2016.
Claims priority of provisional application 62/380,885, filed on Aug. 29, 2016.
Prior Publication US 2022/0160904 A1, May 26, 2022
Int. Cl. A61K 9/00 (2006.01); A61K 51/04 (2006.01); B01D 15/34 (2006.01); B01D 15/38 (2006.01); C07K 14/47 (2006.01); C22B 60/02 (2006.01)
CPC A61K 51/0482 (2013.01) [A61K 51/0478 (2013.01); B01D 15/34 (2013.01); B01D 15/3804 (2013.01); C07K 14/47 (2013.01); C22B 60/02 (2013.01)] 5 Claims
OG exemplary drawing
 
1. A composition comprising a compound or a salt thereof bound to a metal and a siderocalin, the compound having a structure of Formula II:

OG Complex Work Unit Chemistry
wherein:
at least one of R1, R2, R3, R4, and R5, individually, is

OG Complex Work Unit Chemistry
(CAM group);

OG Complex Work Unit Chemistry
(HA group), wherein Ra is H or a C1-C5 alkyl group; or

OG Complex Work Unit Chemistry
(1,2-HOPO group);
at least another one of R1, R2, R3, R4, and R5, individually, is H, an alkyl group having from 1 to 10 carbon atoms;
R6 is (i) H, (ii) an alkyl group having from 1 to 10 carbon atoms, or (iii) an alkyl group having from 1 to 10 carbon atoms and substituted by at least one of SH, NH2, or C(═O) OH;
m is from 1 to 6;
n is from 1 to 6; and
o is from 1 to 6, and wherein the siderocalin comprises any one of SEQ ID NOs: 1-25.