	US 12,257,316 B2
	Nanostructured active ingredient carrier system
Anja Traeger, Trebgast (DE); Anne-Kristin Truetzschler, Jena (DE); Tanja Bus, Jena (DE); and Ulrich Sigmar Schubert, Jena (DE)
Assigned to FRIEDRICH-SCHILLER-UNIVERSITAET JENA, Jena (DE)
Filed by Friedrich-Schiller-Universitaet Jena, Jena (DE)
Filed on Jul. 1, 2022, as Appl. No. 17/810,511.
Application 17/810,511 is a continuation of application No. 16/476,752, granted, now 11,376,336, previously published as PCT/DE2018/100012, filed on Jan. 10, 2018.
Claims priority of application No. 10 2017 100 317.7 (DE), filed on Jan. 10, 2017.
Prior Publication US 2022/0401577 A1, Dec. 22, 2022
Int. Cl. A61K 9/51 (2006.01); A61K 47/54 (2017.01); A61K 47/58 (2017.01); A61K 47/69 (2017.01)

CPC A61K 47/6933 (2017.08) [A61K 9/5153 (2013.01); A61K 47/58 (2017.08)]

16 Claims

1. A nanostructured active ingredient carrier system comprising at least one hydrophobic shell polymer, at least one complexing polymer, and at least one hydrophilic active ingredient, wherein the complexing polymer interacts with the active ingredient, and the complexing polymer comprises primary amino groups, secondary amino groups, or

a combination of primary and secondary amino groups,

and wherein

the hydrophilic active ingredient includes a genetic material, or a peptide, or a protein; and

the complexing polymer includes at least one of a polypeptide, a poly (methacrylate), a polystyrene, a polyamide, a polyacrylamide, a polyurethane, a polyacrylonitrile, a polyethylene glycol, a polyethylene oxide, a polyoxazoline, or any copolymer thereof.