	US 12,257,314 B2
	Extended nitric oxide-releasing polymers via functionalized mesoporous silica nanoparticles
Mark H. Schoenfisch, Chapel Hill, NC (US); and Maggie Malone-Povolny, Carrboro, NC (US)
Assigned to The University of North Carolina at Chapel Hill, Chapel Hill, NC (US)
Appl. No. 17/435,313
Filed by The University of North Carolina at Chapel Hill, Chapel Hill, NC (US)
PCT Filed Feb. 28, 2020, PCT No. PCT/US2020/020443 § 371(c)(1), (2) Date Aug. 31, 2021, PCT Pub. No. WO2020/180705, PCT Pub. Date Sep. 10, 2020.
Claims priority of provisional application 62/812,735, filed on Mar. 1, 2019.
Prior Publication US 2022/0152219 A1, May 19, 2022
Int. Cl. A61K 47/69 (2017.01); A61K 9/14 (2006.01); A61K 33/00 (2006.01)

CPC A61K 47/6923 (2017.08) [A61K 9/146 (2013.01); A61K 33/00 (2013.01); A61K 47/6929 (2017.08)]

18 Claims

1. A nitric oxide releasing particle, comprising:

nitric oxide donors;

a mesoporous silica network; and

an exterior surface,

wherein said nitric oxide donors are present within pores of said mesoporous silica network and on the exterior surface of said particle,

wherein said nitric oxide releasing particle comprises an amount of nitric oxide donors such that the particle exhibits a total nitric oxide release duration of at least 49 hours, and

wherein said nitric oxide donors are nitrosothiols.