	US 12,257,309 B2
	Zwitterionic polymer-insulin compositions and related methods
Zhiqiang Cao, Troy, MI (US)
Assigned to Wayne State University, Detroit, MI (US)
Filed by Wayne State University, Detroit, MI (US)
Filed on Jan. 5, 2022, as Appl. No. 17/569,129.
Application 17/569,129 is a division of application No. 16/478,352, abandoned, previously published as PCT/US2018/014038, filed on Jan. 17, 2018.
Claims priority of provisional application 62/453,851, filed on Feb. 2, 2017.
Claims priority of provisional application 62/447,048, filed on Jan. 17, 2017.
Prior Publication US 2022/0125937 A1, Apr. 28, 2022
Int. Cl. A61K 47/58 (2017.01); A61K 38/28 (2006.01); A61K 47/54 (2017.01); A61K 47/69 (2017.01); A61P 3/10 (2006.01)

CPC A61K 47/58 (2017.08) [A61K 38/28 (2013.01); A61K 47/549 (2017.08); A61K 47/6903 (2017.08); A61P 3/10 (2018.01)]

2 Claims

1. A composition, comprising:

a zwitterionic polymer-insulin-saccharide composition comprising a zwitterionic polymer-insulin composition covalently bonded to a saccharide moiety or a saccharide monomer; and

a lectin in physical mixture with the zwitterionic polymer-insulin-saccharide composition, wherein the lectin binds to the saccharide of the zwitterionic polymer-insulin-saccharide composition, forming a glucose-responsive zwitterionic polymer-insulin-saccharide composition.