US 12,257,308 B2
Stimuli-responsive PEG-like polymer-based drug delivery platform
Ashutosh Chilkoti, Durham, NC (US); and Imran Ozer, Durham, NC (US)
Assigned to Duke University, Durham, NC (US)
Appl. No. 17/051,202
Filed by Duke University, Durham, NC (US)
PCT Filed Apr. 30, 2019, PCT No. PCT/US2019/030022
§ 371(c)(1), (2) Date Oct. 28, 2020,
PCT Pub. No. WO2019/213150, PCT Pub. Date Nov. 7, 2019.
Claims priority of provisional application 62/664,512, filed on Apr. 30, 2018.
Prior Publication US 2021/0128734 A1, May 6, 2021
Int. Cl. A61K 47/58 (2017.01); A61K 38/22 (2006.01); A61P 3/10 (2006.01)
CPC A61K 47/58 (2017.08) [A61K 38/2278 (2013.01); A61P 3/10 (2018.01)] 18 Claims
OG exemplary drawing
 
1. A thermally responsive polymer-therapeutic molecule conjugate comprising:
a backbone comprising 100 to 600 repeating monomer units selected from the group consisting of acrylate, methacrylate, acrylamide, methacrylamide, and combinations thereof;
a plurality of oligoethylene glycol side chains; and
a therapeutic molecule conjugated to the backbone;
wherein each oligoethylene glycol side chain is covalently attached at a first end to the backbone and each oligoethylene glycol side chain comprises two or three monomers of ethylene glycol repeated in tandem,
wherein between 45% and 85% of the plurality of oligoethylene glycol side chains comprise two monomers of ethylene glycol repeated in tandem, and
wherein the conjugate has a transition temperature between 23° C. and 40° C.