US 12,257,305 B2
Cationic lipid compounds
Frank DeRosa, Lexington, MA (US); Shrirang Karve, Lexington, MA (US); and Yi Zhang, Lexington, MA (US)
Assigned to TRANSLATE BIO, INC., Waltham, MA (US)
Appl. No. 17/295,621
Filed by Translate Bio, Inc., Lexington, MA (US)
PCT Filed Nov. 20, 2019, PCT No. PCT/US2019/062504
§ 371(c)(1), (2) Date May 20, 2021,
PCT Pub. No. WO2020/106903, PCT Pub. Date May 28, 2020.
Claims priority of provisional application 62/770,309, filed on Nov. 21, 2018.
Prior Publication US 2023/0050672 A1, Feb. 16, 2023
Int. Cl. C07C 215/24 (2006.01); A61K 9/1272 (2025.01); A61K 47/14 (2017.01); A61K 47/54 (2017.01); C07C 217/08 (2006.01); C07C 229/12 (2006.01)
CPC A61K 47/14 (2013.01) [A61K 9/1272 (2013.01); A61K 47/543 (2017.08); C07C 215/24 (2013.01); C07C 217/08 (2013.01); C07C 229/12 (2013.01)] 14 Claims
 
1. A cationic lipid having a structure according to Formula (I):

OG Complex Work Unit Chemistry
wherein:
each L1 is independently C2-C12-alkenylene;
each A1 is independently a linker group that is a covalent bond, O, S, NH, S—S, an amide, an ester, a thioester, or an anhydride group;
each R1 is an ionizable nitrogen-containing group;
each m is independently an integer of 6 to 20; and
each n is independently an integer of 1 to 6.