US 12,257,297 B2
Vaccine compositions having improved stability and immunogenicity
Gale Smith, Germantown, MD (US); Ye Liu, Clarksville, MD (US); Jing-Hui Tian, Germantown, MD (US); Michael J. Massare, Mt. Airy, MD (US); Sarathi Boddapati, Germantown, MD (US); Erica Shane, McLean, VA (US); Cynthia Oliver, Potomac, MD (US); and Gregory Glenn, Poolesville, MD (US)
Filed by Novavax, Inc., Gaithersburg, MD (US)
Filed on May 23, 2022, as Appl. No. 17/750,612.
Application 17/750,612 is a continuation of application No. 15/819,962, filed on Nov. 21, 2017, granted, now 11,364,294.
Application 15/819,962 is a continuation of application No. 15/257,436, filed on Sep. 6, 2016, granted, now 10,426,829, issued on Oct. 1, 2019.
Claims priority of provisional application 62/350,973, filed on Jun. 16, 2016.
Claims priority of provisional application 62/309,216, filed on Mar. 16, 2016.
Claims priority of provisional application 62/255,786, filed on Nov. 16, 2015.
Claims priority of provisional application 62/213,947, filed on Sep. 3, 2015.
Prior Publication US 2022/0387579 A1, Dec. 8, 2022
Int. Cl. C12N 7/00 (2006.01); A61K 9/00 (2006.01); A61K 9/16 (2006.01); A61K 39/12 (2006.01); A61K 39/155 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/155 (2013.01) [A61K 9/0019 (2013.01); A61K 9/1611 (2013.01); A61K 9/1617 (2013.01); A61K 39/12 (2013.01); C12N 7/00 (2013.01); A61K 2039/54 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55555 (2013.01); C12N 2710/14143 (2013.01); C12N 2760/14134 (2013.01); C12N 2760/14171 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16151 (2013.01); C12N 2760/16222 (2013.01); C12N 2760/16234 (2013.01); C12N 2760/16251 (2013.01); C12N 2760/18522 (2013.01); C12N 2760/18534 (2013.01)] 30 Claims
 
1. A nanoparticle comprising: an Ebola virus glycoprotein (GP) and a non-ionic detergent core;
wherein the GP comprises a GP1 domain and a GP2 domain;
wherein the GP1 domain and GP2 domain are connected via a disulfide bond;
wherein the GP2 polypeptide is associated with the non-ionic detergent core and the GP1 polypeptide extends outward; and
wherein the GP is a trimer.