US 12,257,290 B2
PIC1 inhibition of myeloperoxidase oxidative activity in an animal model
Neel K. Krishna, Norfolk, VA (US); and Kenji Cunnion, Norfolk, VA (US)
Assigned to REALTA HOLDINGS, LLC, Norfolk, VA (US)
Filed by REALTA HOLDINGS, LLC, Norfolk, VA (US)
Filed on Jun. 9, 2023, as Appl. No. 18/332,026.
Application 18/332,026 is a continuation of application No. 17/245,213, filed on Apr. 30, 2021, granted, now 11,712,462.
Application 17/245,213 is a continuation of application No. 16/839,464, filed on Apr. 3, 2020, granted, now 11,020,460, issued on Jun. 1, 2021.
Application 16/839,464 is a continuation of application No. 16/242,550, filed on Jan. 8, 2019, granted, now 11,135,272, issued on Oct. 5, 2021.
Claims priority of provisional application 62/746,649, filed on Oct. 17, 2018.
Claims priority of provisional application 62/681,458, filed on Jun. 6, 2018.
Claims priority of provisional application 62/615,183, filed on Jan. 9, 2018.
Prior Publication US 2023/0321201 A1, Oct. 12, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/00 (2006.01); A61K 9/00 (2006.01); A61K 38/08 (2019.01); A61K 38/43 (2006.01); A61K 47/10 (2017.01); A61P 37/06 (2006.01); C07K 14/005 (2006.01); C07K 14/47 (2006.01)
CPC A61K 38/43 (2013.01) [A61K 9/0019 (2013.01); A61K 38/005 (2013.01); A61K 38/08 (2013.01); A61K 47/10 (2013.01); A61P 37/06 (2018.01); C07K 14/005 (2013.01); C07K 14/4703 (2013.01); C12N 2770/00022 (2013.01); C12N 2770/00033 (2013.01)] 10 Claims
 
1. A method of reducing myeloperoxidase (MPO) levels in a subject, the method comprising:
administering a therapeutically effective amount of a PIC1 peptide to the subject in need thereof, wherein the PIC1 peptide comprises the sequence of IALILEPICCQERAA-dPEG24 (SEQ ID NO: 19),
wherein the PIC1 peptide is administered at a dose of from 5 to 160 mg/kg body weight of the subject.