US 12,257,289 B2
Self-assembling oxygen carrier compositions
Dipanjan Pan, Ellicot City, MD (US); Allan Doctor, Towson, MD (US); and Philip C. Spinella, Chesterfiled, MO (US)
Assigned to KaloCyte, Inc., Baltimore, MD (US)
Filed by KaloCyte, Inc., Baltimore, MD (US)
Filed on Apr. 23, 2021, as Appl. No. 17/238,809.
Claims priority of provisional application 63/014,665, filed on Apr. 23, 2020.
Prior Publication US 2021/0330754 A1, Oct. 28, 2021
Int. Cl. A61K 38/42 (2006.01); A61K 9/127 (2006.01); A61K 9/1277 (2025.01); A61K 9/19 (2006.01); A61K 47/24 (2006.01); A61K 47/28 (2006.01); C07F 9/10 (2006.01)
CPC A61K 38/42 (2013.01) [A61K 9/1277 (2013.01); A61K 9/19 (2013.01); A61K 47/24 (2013.01); A61K 47/28 (2013.01); C07F 9/10 (2013.01)] 9 Claims
 
1. A composition comprising:
(a) a phospholipid,
(b) cholesterol,
(c) an oxygen carrier,
(d) a lipid-amphiphile precursor compound, and
(e) an allosteric effector,
the lipid-amphiphile precursor having the formula:

OG Complex Work Unit Chemistry
or a salt or tautomer thereof, wherein:
R1 is a hydrophobic group,
R2 is

OG Complex Work Unit Chemistry
and
R3 is chosen from

OG Complex Work Unit Chemistry