	US 12,257,284 B2
	Lantibiotics, lantibiotic-producing bacteria, compositions and methods of production and use thereof
Eric Pamer, Montclair, NJ (US); Sohn Kim, New York, NY (US); Peter McKenney, New York, NY (US); and Silvia Caballero, Cambridge, MA (US)
Assigned to MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US)
Filed by MEMORIAL SLOAN-KETTERING CANCER CENTER, New York, NY (US)
Filed on Dec. 28, 2021, as Appl. No. 17/563,772.
Application 17/563,772 is a continuation of application No. 16/659,199, filed on Oct. 21, 2019, granted, now 11,207,374, issued on Dec. 28, 2021.
Application 16/659,199 is a continuation of application No. PCT/US2018/028629, filed on Apr. 20, 2018.
Claims priority of provisional application 62/488,480, filed on Apr. 21, 2017.
Prior Publication US 2022/0370547 A1, Nov. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/00 (2006.01); A61K 38/12 (2006.01); A61K 38/44 (2006.01); A61P 31/04 (2006.01); C12N 1/20 (2006.01); C12P 21/00 (2006.01)

CPC A61K 38/12 (2013.01) [A61K 38/443 (2013.01); A61P 31/04 (2018.01); C12N 1/20 (2013.01); C12P 21/00 (2013.01); C12Y 101/0112 (2013.01)]

20 Claims

1. A method of treating a gram-positive bacteria colonization or infection, wherein the method comprises administering to a patient in need of such treatment, a therapeutically effective amount of a pharmaceutical composition comprising an isolated lantibiotic comprising a domain having the amino acid sequence of SEQ ID NO: 3 and a pharmaceutical acceptable carrier.