US 12,257,280 B2
Composition for preventing or treating muscular diseases, containing, as active ingredient, Glycyrrhiza uralensis extract or compound isolated therefrom
Inho Choi, Gyeongsan-si (KR); Eun Ju Lee, Daegu (KR); So-young Park, Daegu (KR); Yong-Ho Lee, Daegu (KR); Jin Yeul Ma, Daejeon (KR); Won-Kyung Cho, Daegu (KR); and Hye Jin Yang, Daejeon (KR)
Assigned to NEO CREMAR CO., LTD., Seoul (KR)
Appl. No. 17/266,610
Filed by NEO CREMAR CO., LTD., Seoul (KR)
PCT Filed Jun. 17, 2020, PCT No. PCT/KR2020/007826
§ 371(c)(1), (2) Date Feb. 7, 2021,
PCT Pub. No. WO2020/256397, PCT Pub. Date Dec. 24, 2020.
Claims priority of application No. 10-2019-0072992 (KR), filed on Jun. 19, 2019; application No. 10-2020-0073088 (KR), filed on Jun. 16, 2020; application No. 10-2020-0073089 (KR), filed on Jun. 16, 2020; application No. 10-2020-0073090 (KR), filed on Jun. 16, 2020; application No. 10-2020-0073091 (KR), filed on Jun. 16, 2020; and application No. 10-2020-0073092 (KR), filed on Jun. 16, 2020.
Prior Publication US 2021/0315957 A1, Oct. 14, 2021
Int. Cl. A61K 36/484 (2006.01); A23L 33/00 (2016.01); A23L 33/105 (2016.01); A61K 9/00 (2006.01); A61K 31/12 (2006.01); A61K 31/353 (2006.01); A61P 21/00 (2006.01)
CPC A61K 36/484 (2013.01) [A23L 33/105 (2016.08); A23L 33/40 (2016.08); A61K 9/0056 (2013.01); A61K 31/12 (2013.01); A61K 31/353 (2013.01); A61P 21/00 (2018.01); A23V 2002/00 (2013.01); A61K 2236/331 (2013.01); A61K 2236/333 (2013.01)] 7 Claims
 
1. A method of preventing or treating muscle diseases in a subject, comprising:
providing a pharmaceutical composition comprising licorice extract containing a compound represented by the following formula 3, as an active ingredient,

OG Complex Work Unit Chemistry
and
administering the pharmaceutical composition to the subject, wherein the muscle diseases are prevented or treated, wherein the muscle diseases are selected from the group consisting of muscular dystrophy, sarcopenia, myopathy, and myasthenia,
wherein the compound is obtained by extracting licorice with distilled water at 110 to 120° C. for 2 to 4 hours and fractioning the licorice extract with dichloromethane ethyl acetate or N-butanol.