US 12,257,256 B2
Compositions and methods for inhibiting type 1 collagen production
Branko Stefanovic, Tallahassee, FL (US)
Assigned to Florida State University Research Foundation, Inc., Tallahassee, FL (US)
Filed by Florida State University Research Foundation, Inc., Tallahassee, FL (US)
Filed on Nov. 22, 2022, as Appl. No. 17/992,290.
Application 17/992,290 is a continuation of application No. 17/217,091, filed on Mar. 30, 2021, granted, now 11,554,121.
Claims priority of provisional application 63/001,866, filed on Mar. 30, 2020.
Prior Publication US 2023/0087749 A1, Mar. 23, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/542 (2006.01); A61P 19/04 (2006.01)
CPC A61K 31/542 (2013.01) [A61P 19/04 (2018.01)] 14 Claims
OG exemplary drawing
 
1. A composition comprising a pharmaceutical dosage form that is substantially cephalosporin free and includes an antifibrotic compound of formula

OG Complex Work Unit Chemistry
Wherein R1 includes at least one member selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, hydroxy, carboxy, acyl, nitro, phosphor, halo, sulfo, ester, ether, and amino; and R2 is selected from

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof.