US 12,257,249 B2
Methods for treating depressive symptoms
Laura Cook Blumberg, Lincoln, MA (US); Daniel R. Deaver, Franklin, MA (US); David J. Eyerman, Wayland, MA (US); and Thomas Andrew Wynn, Lexington, MA (US)
Assigned to Alkermes Pharma Ireland Limited, Dublin (IE)
Filed by Alkermes Pharma Ireland Limited, Dublin (IE)
Filed on Nov. 18, 2022, as Appl. No. 18/056,975.
Application 18/056,975 is a division of application No. 16/913,404, filed on Jun. 26, 2020, granted, now 11,534,436.
Application 16/913,404 is a division of application No. 16/272,654, filed on Feb. 11, 2019, granted, now 10,736,890, issued on Aug. 11, 2020.
Application 16/272,654 is a division of application No. 15/489,377, filed on Apr. 17, 2017, granted, now 10,231,963, issued on Mar. 19, 2019.
Application 15/489,377 is a division of application No. 14/286,499, filed on May 23, 2014, granted, now 9,656,961, issued on May 23, 2017.
Claims priority of provisional application 61/827,295, filed on May 24, 2013.
Claims priority of provisional application 61/827,317, filed on May 24, 2013.
Prior Publication US 2023/0158017 A1, May 25, 2023
Int. Cl. A61K 31/485 (2006.01); C07D 211/62 (2006.01); C07D 217/04 (2006.01); C07D 221/22 (2006.01); C07D 221/28 (2006.01); C07D 223/04 (2006.01); C07D 401/12 (2006.01); C07D 405/12 (2006.01); C07D 489/00 (2006.01); C07D 489/09 (2006.01)
CPC A61K 31/485 (2013.01) [C07D 211/62 (2013.01); C07D 217/04 (2013.01); C07D 221/22 (2013.01); C07D 221/28 (2013.01); C07D 223/04 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01); C07D 489/00 (2013.01); C07D 489/09 (2013.01)] 15 Claims
 
1. A method of treating a depressive symptom in a subject comprising administering to the subject a compound selected from:

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt thereof;
wherein the depressive symptom is depressed mood, loss of pleasure, loss of appetite, sleep disturbance, psychomotor changes, fatigue, post-partum depression, associated with a mental condition, acute stress disorder, adjustment disorders with depressed mood, Asperger syndrome, attention deficit, bereavement, bipolar I disorder, bipolar II disorder, borderline and personality disorder, cyclothymia and dysthymia, major depressive disorder (MDD), treatment-resistant disorder (TRD), Dysthymic disorder, hyperactivity disorder, impulse control disorder, mixed mania, obsessive-compulsive personality disorder (OCD), paranoid, post-traumatic stress disorder, seasonal affective disorder, self-injury separation, sleep disorder, substance-induced mood disorder, Tourette syndrome and tic disorder, Trichotillomania, or an anxiety disorder.