US 12,257,240 B2
Combination of berberine and derivatives thereof, and vitamin B12
Shawn Wells, Lewisville, TX (US); Ronghua Yi, Nanjing (CN); Mingru Wang, Nanjing (CN); and Kylin Liao, Nanjing (CN)
Assigned to NANJING NUTRABUILDING BIO-TECH CO., LTD., Nanjing (CN)
Filed by NANJING NUTRABUILDING BIO-TECH CO., LTD., Nanjing (CN)
Filed on Aug. 23, 2022, as Appl. No. 17/893,634.
Prior Publication US 2023/0067847 A1, Mar. 2, 2023
Int. Cl. A61K 31/4375 (2006.01); A61K 31/714 (2006.01); A61P 7/00 (2006.01)
CPC A61K 31/4375 (2013.01) [A61K 31/714 (2013.01); A61P 7/00 (2018.01)] 10 Claims
 
1. A method of maintaining or improving intestinal balance in a mammal, the method comprising
administrating to the mammal an effective amount of
(i) berberine (BBR), or a pharmaceutically acceptable salt, acid, or ester thereof, wherein the BBR is dihydroberberine (DHB) which is a hydrogenated derivative of BBR; and
(ii) vitamin B 12 (VB12) in a ratio of the DHB over the VB12 at 2:98 to 98:2 by weight,
to obtain intestinal balance of short chain fatty acid (SCFAs) contents or gut microbiota diversity and richness in the mammal.