	US 12,257,233 B2
	Methods
Anthony Alexander McKinney, Boston, MA (US)
Assigned to Ethismos Research, Inc., Cambridge, MA (US)
Filed by Ethismos Research, Inc., Cambridge, MA (US)
Filed on Sep. 7, 2022, as Appl. No. 17/939,508.
Application 17/939,508 is a continuation of application No. 16/751,186, filed on Jan. 23, 2020, granted, now 11,471,438.
Application 16/751,186 is a continuation in part of application No. PCT/US2019/069143, filed on Dec. 31, 2019.
Claims priority of provisional application 62/928,294, filed on Oct. 30, 2019.
Claims priority of provisional application 62/927,634, filed on Oct. 29, 2019.
Claims priority of provisional application 62/787,118, filed on Dec. 31, 2018.
Prior Publication US 2023/0090174 A1, Mar. 23, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/403 (2006.01); A61P 23/00 (2006.01); A61P 25/36 (2006.01)

CPC A61K 31/403 (2013.01) [A61P 23/00 (2018.01); A61P 25/36 (2018.01)]

27 Claims

1. A method of reducing daily opioid dose in a patient being treated with an opioid, wherein the method comprises coordinately administering to the patient (1R,5S)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, in free or pharmaceutically acceptable salt form, and the opioid.