US 12,257,228 B2
Cardioversion methods using budiodarone
Pascal Druzgala, Santa Rosa, CA (US); and Peter Gerard Milner, Mountain View, CA (US)
Assigned to Xyra, LLC, Santa Rosa, CA (US)
Filed by Xyra, LLC, Santa Rosa, CA (US)
Filed on Jul. 12, 2023, as Appl. No. 18/351,261.
Claims priority of provisional application 63/525,014, filed on Jul. 5, 2023.
Prior Publication US 2025/0009708 A1, Jan. 9, 2025
Int. Cl. A61K 31/343 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 31/4545 (2006.01); A61K 31/5377 (2006.01); A61P 9/06 (2006.01)
CPC A61K 31/343 (2013.01) [A61K 31/4439 (2013.01); A61K 31/444 (2013.01); A61K 31/4545 (2013.01); A61K 31/5377 (2013.01); A61P 9/06 (2018.01)] 24 Claims
 
1. A method for cardioverting a patient having an extended episode of paroxysmal or persistent AFib and who is deemed suitable for cardioversion, said method comprising:
a) administering a single oral dose of budiodarone or a pharmaceutically acceptable salt thereof to said patient in an amount from about 900 mg to about 2,000 mg, wherein the amount is sufficient to provide for a peak budiodarone blood plasma concentration in said patient of at least about 50 ng/mL and maintain a budiodarone blood plasma concentration in said patient of at least about 13 ng/mL for at least 6 hours wherein said patient's AFib heart rhythm cardioverts to sinus rhythm; and
b) monitoring a heart rhythm of said patient, subsequent to said administering, until the budiodarone blood plasma concentration is measured to be below about 20 ng/mL.