US 12,257,221 B2
Leucine-enriched ketogenic formulations
Susan Gingrich, Ayer, MA (US); Robert Reed, Itasca, IL (US); Kenji Nagao, Tokyo (JP); and Natsumi Nishikata, Tokyo (JP)
Assigned to AJINOMOTO CO., INC., Tokyo (JP)
Filed by AJINOMOTO CO., INC., Tokyo (JP)
Filed on Mar. 24, 2021, as Appl. No. 17/301,076.
Application 17/301,076 is a continuation of application No. PCT/IB2019/001126, filed on Oct. 2, 2019.
Claims priority of provisional application 62/741,506, filed on Oct. 4, 2018.
Prior Publication US 2021/0205252 A1, Jul. 8, 2021
Int. Cl. A61K 31/198 (2006.01); A23L 33/00 (2016.01); A23L 33/115 (2016.01); A23L 33/155 (2016.01); A23L 33/19 (2016.01); A23L 33/29 (2016.01); A61K 8/44 (2006.01); A61K 9/00 (2006.01); A61P 25/08 (2006.01)
CPC A61K 31/198 (2013.01) [A23L 33/115 (2016.08); A23L 33/155 (2016.08); A23L 33/19 (2016.08); A23L 33/29 (2016.08); A23L 33/30 (2016.08); A23L 33/40 (2016.08); A61K 8/44 (2013.01); A61K 9/0053 (2013.01); A61P 25/08 (2018.01); A61K 2800/92 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A ketogenic composition comprising: fat, a protein source, and carbohydrate, wherein: (a) the fat provides 60-90% of total calories of the composition and medium chain triglycerides (MCTs) provide between 10-40% of total calories of the composition; (b) the protein source comprises a non-casein protein and a leucine-enriched amino acid mixture; (c) and the ratio of calories fat to calories combined protein and net carbohydrate ranges from about 2:1 to about 4:1,
wherein the leucine-enriched amino acid mixture comprises L-leucine, L-histidine, L-isoleucine, L-lysine, L-methionine, L-phenylalanine, L-threonine, L-tryptophan, and L-valine, and comprises leucine at a molar ratio between 30% and 70% with respect to total essential amino acids in the mixture.