US 12,257,220 B2
Composition for improving endurance and method of improving endurance using the same
Hiroaki Iitsuka, Kyoto (JP); Yugweng Kim, Kyoto (JP); Maya Sakashita, Kyoto (JP); Atsushi Yamatsu, Kyoto (JP); Mujo Kim, Kyoto (JP); and Wataru Aoi, Kyoto (JP)
Assigned to PHARMA FOODS INTERNATIONAL CO., LTD., Kyoto (JP); and KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, Kyoto (JP)
Filed by PHARMA FOODS INTERNATIONAL CO., LTD., Kyoto (JP); and KYOTO PREFECTURAL PUBLIC UNIVERSITY CORPORATION, Kyoto (JP)
Filed on Feb. 19, 2021, as Appl. No. 17/179,943.
Claims priority of application No. 2020-28755 (JP), filed on Feb. 21, 2020.
Prior Publication US 2021/0322352 A1, Oct. 21, 2021
Int. Cl. A61K 31/197 (2006.01); A23L 33/17 (2016.01); A61P 21/00 (2006.01)
CPC A61K 31/197 (2013.01) [A23L 33/17 (2016.08); A61P 21/00 (2018.01)] 13 Claims
OG exemplary drawing
 
1. A method of increasing slow muscle development in a subject, the method comprising:
administering an effective amount of γ-aminobutyric acid (GABA) to the subject via daily ingestion for correspondingly increasing slow muscle development in the subject while the subject is in a physically active state defined as engaging in one or more physical activities relative to a physically inactive state defined as the subject being substantially idle, wherein:
daily administration of the effective amount of GABA over a test period of two consecutive weeks results in an approximate two-fold increase in aerobic performance at an end of the test period, compared to non-administration of the effective amount of GABA over the test period of two consecutive weeks,
wherein one or more physical activities comprises walking, jogging, running, or manual labors and physical activities in daily life,
wherein an intensity of the one or more physical activities is 3 to 6 METs, and
wherein completion of administering the effective amount of GABA results in an increase in an amount of expression of PGC-1α in a skeletal muscle, and the increase of the amount of expression of PGC-1α leads to enhancement of the amount of the slow muscle.