US 12,257,216 B2
Treatment for hot flushes
Andrej A. Romanovsky, San Francisco, CA (US)
Assigned to Dignity Health, San Francisco, CA (US)
Filed by Dignity Health, San Francisco, CA (US)
Filed on Oct. 14, 2022, as Appl. No. 18/046,876.
Application 18/046,876 is a continuation of application No. 16/628,208, abandoned, previously published as PCT/US2018/040902, filed on Jul. 5, 2018.
Claims priority of provisional application 62/529,269, filed on Jul. 6, 2017.
Prior Publication US 2023/0135909 A1, May 4, 2023
Int. Cl. A61K 31/17 (2006.01); A61K 9/00 (2006.01); A61K 31/167 (2006.01); A61K 31/4725 (2006.01); A61K 31/55 (2006.01); A61K 45/06 (2006.01)
CPC A61K 31/17 (2013.01) [A61K 9/0014 (2013.01); A61K 31/167 (2013.01); A61K 31/4725 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A method for treating thermal discomfort associated with hot flushes in a subject in need thereof, comprising:
administering a therapeutically effective amount of a composition to the subject, wherein the composition comprises a transient receptor potential subfamily V member 1 channel (TRPV1 channel) antagonist having a structure of

OG Complex Work Unit Chemistry
or
a salt thereof; and
wherein the therapeutically effective amount comprises the amount effective in suppressing, ameliorating, alleviating, and/or preventing the thermal discomfort in the subject, while not impacting vasodilation.