US 12,257,153 B2
Methods for carbonate surface coating and related bone void filler compositions
Lawrence A. Shimp, Burlington, WI (US)
Assigned to CaP BIOMATERIALS, LLC, East Troy, WI (US)
Filed by CaP Biomaterials, LLC, East Troy, WI (US)
Filed on Aug. 16, 2021, as Appl. No. 17/402,995.
Application 16/531,830 is a division of application No. 15/812,847, filed on Nov. 14, 2017, granted, now 10,368,995, issued on Aug. 6, 2019.
Application 17/402,995 is a continuation of application No. 16/531,830, filed on Aug. 5, 2019, granted, now 11,116,638.
Claims priority of provisional application 62/421,541, filed on Nov. 14, 2016.
Prior Publication US 2021/0369462 A1, Dec. 2, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61F 2/30 (2006.01); A61L 27/24 (2006.01); A61L 27/30 (2006.01); A61L 27/32 (2006.01); A61L 27/36 (2006.01); A61L 27/50 (2006.01); A61L 27/56 (2006.01); A61L 31/00 (2006.01); A61L 31/04 (2006.01); A61L 31/08 (2006.01); A61L 31/14 (2006.01); A61F 2/28 (2006.01); A61L 27/54 (2006.01); A61L 27/58 (2006.01)
CPC A61F 2/30767 (2013.01) [A61L 27/24 (2013.01); A61L 27/306 (2013.01); A61L 27/32 (2013.01); A61L 27/3608 (2013.01); A61L 27/50 (2013.01); A61L 27/56 (2013.01); A61L 31/005 (2013.01); A61L 31/044 (2013.01); A61L 31/088 (2013.01); A61L 31/14 (2013.01); A61L 31/146 (2013.01); A61F 2002/2835 (2013.01); A61L 27/54 (2013.01); A61L 27/58 (2013.01); A61L 2420/02 (2013.01); A61L 2430/02 (2013.01)] 8 Claims
 
1. A method of using comparative calcium salt solubilities to prepare a bone void filler substrate comprising calcium particles thereon, said method comprising:
providing a carbonatable calcium salt precursor component having a water solubility;
applying said precursor component to a bone void filler substrate comprising a material selected from calcium salts, collagen, natural mammalian bone, polymers, metals and combinations thereof; and
treating said applied precursor component with a transformation component selected from alkali metal hydroxide and alkali metal carbonate components to provide on said substrate a calcium component having a water solubility less than said precursor component water solubility, said calcium component selected from calcium hydroxide and calcium carbonate particles.