US 12,257,072 B2
Mapping and quantifying shear stress and hemolysis in patients
Juan Carlos del Alamo de Pedro, San Diego, CA (US); Lorenzo Rossini, San Diego, CA (US); Andrew Kahn, San Diego, CA (US); Javier Bermejo, Madrid (ES); Pablo Martínez-Legazpi, Madrid (ES); and Raquel Yotti Alvarez, Madrid (ES)
Assigned to The Regents of the University of California et al., Oakland, CA (US)
Filed by The Regents of the University of California; and Fundación para la Investigación Biomédica del Hospital Gregorio Marañó, Madrid (ES)
Filed on Sep. 28, 2022, as Appl. No. 17/955,077.
Application 17/955,077 is a continuation of application No. 17/045,351, granted, now 11,471,101, previously published as PCT/US2019/026146, filed on Apr. 5, 2019.
Claims priority of provisional application 62/653,365, filed on Apr. 5, 2018.
Claims priority of provisional application 62/653,389, filed on Apr. 5, 2018.
Prior Publication US 2023/0050982 A1, Feb. 16, 2023
Int. Cl. A61B 5/00 (2006.01); A61B 5/02 (2006.01); A61B 5/026 (2006.01); A61B 5/0285 (2006.01); A61B 5/055 (2006.01); A61B 8/00 (2006.01); A61B 8/06 (2006.01); A61B 8/08 (2006.01); A61M 60/178 (2021.01); A61M 60/857 (2021.01); G16H 30/40 (2018.01); G16H 50/30 (2018.01)
CPC A61B 5/4851 (2013.01) [A61B 5/02035 (2013.01); A61B 5/0263 (2013.01); A61B 5/0285 (2013.01); A61B 5/055 (2013.01); A61B 5/7225 (2013.01); A61B 8/06 (2013.01); A61B 8/065 (2013.01); A61B 8/0883 (2013.01); A61B 8/485 (2013.01); A61B 8/488 (2013.01); A61B 8/5223 (2013.01); A61M 60/178 (2021.01); A61M 60/857 (2021.01); G16H 30/40 (2018.01); G16H 50/30 (2018.01); A61M 2205/04 (2013.01); A61M 2250/00 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method performed by one or more computers, the method comprising:
obtaining a plurality of flow-velocity images of blood inside a cardiac chamber or blood vessel of a subject;
processing the plurality of flow-velocity images to generate a Von-Mises stress map, wherein the Von-Mises stress map defines a respective amount of Von-Mises stress experienced by blood particles at each of a plurality of time points and at each of a plurality of spatial positions inside the cardiac chamber or blood vessel;
processing the plurality of flow-velocity images to generate a residence time map, wherein the residence time map defines a respective residence time of blood particles at each of a plurality of spatial positions inside the cardiac chamber or blood vessel;
generating a cumulative fluid shear stress map as a function of the Von-Mises stress map using a transport equation, wherein the cumulative fluid shear stress map defines a respective cumulative amount of fluid shear stress experienced by blood particles at each of a plurality of spatial positions inside the cardiac chamber or blood vessel over the plurality of time points; and
processing: (i) the cumulative fluid shear stress map, and (ii) the residence time map, to identify one or more regions of hemolysis inside the cardiac chamber or blood vessel.