US 12,257,033 B2
System, computer system and computer program for determining a cardiovascular parameter
Wolfgang Huber, Gmund (DE); Mark Konrad, Munich (DE); and Sergej Kammerzell, Munich (DE)
Assigned to Pulsion Medical Systems SE, Feldkirchen (DE)
Appl. No. 17/287,046
Filed by Pulsion Medical Systems SE, Feldkirchen (DE)
PCT Filed Oct. 21, 2019, PCT No. PCT/EP2019/078571
§ 371(c)(1), (2) Date Nov. 3, 2021,
PCT Pub. No. WO2020/083836, PCT Pub. Date Apr. 30, 2020.
Claims priority of application No. 10 2018 008 356.0 (DE), filed on Oct. 22, 2018.
Prior Publication US 2022/0079453 A1, Mar. 17, 2022
Int. Cl. A61B 5/0205 (2006.01); A61B 5/029 (2006.01); A61B 5/0295 (2006.01)
CPC A61B 5/0205 (2013.01) [A61B 5/029 (2013.01); A61B 5/0295 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A system for determining a cardiovascular parameter of a patient, configured to interact with an apparatus for extracorporeal blood treatment connected to a venous vascular system of a vascular system of the patient via an inflow line attached at a first point in the venous vascular system and an outflow line attached at a second point in the venous vascular system, wherein the extracorporeal blood treatment apparatus comprises at least one pump arranged between the inflow line and the outflow line for moving the blood of the patient within the extracorporeal blood treatment apparatus, the system comprising:
a. a temperature influencing means for causing an initial local temperature deviation (T1) in the vicinity of the second point of the venous vascular system of the patient, so that a traveling temperature change is introduced in the blood flow of the patient;
b. a first temperature sensor for measuring an intracorporeal temperature of the blood of the patient at a third point in the vascular system of the patient downstream of the second point;
c. a second temperature sensor for measuring a local temperature of the blood of the patient in the inflow line of the extracorporeal blood treatment apparatus; and
d. a computer system connected to the first temperature sensor and the second temperature sensor and configured to record the local temperature of the blood of the patient at the third point in the vascular system of the patient and the local temperature of the blood of the patient in the inflow line of the extracorporeal blood treatment apparatus as a function of time, and to determine and evaluate a first and a second thermodilution curve (TDK1, TDK2), and wherein the computer system is further configured to determine, from the second thermodilution curve, a temperature deviation (TEKBV) which is to be allocated to the extracorporeal blood treatment apparatus, and to correlate T1 and TEKBV to determine the cardiovascular parameter.