US 11,935,625 B2
Methods and systems for genomic analysis
Jason Harris, San Carlos, CA (US); Mark R. Pratt, Menlo Park, CA (US); John West, Cupertino, CA (US); Richard Chen, Burlingame, CA (US); and Ming Li, Fremont, CA (US)
Assigned to PERSONALIS, INC., Fremont, CA (US)
Filed by Personalis, Inc., Menlo Park, CA (US)
Filed on Nov. 19, 2020, as Appl. No. 16/952,507.
Application 16/952,507 is a continuation of application No. 16/849,121, filed on Apr. 15, 2020, abandoned.
Application 16/849,121 is a continuation of application No. 16/559,423, filed on Sep. 3, 2019, abandoned.
Application 16/559,423 is a continuation of application No. 16/226,592, filed on Dec. 19, 2018, abandoned.
Application 16/226,592 is a continuation of application No. 15/967,280, filed on Apr. 30, 2018, abandoned.
Application 15/967,280 is a continuation of application No. 15/639,610, filed on Jun. 30, 2017, granted, now 10,032,000, issued on Jul. 24, 2018.
Application 15/639,610 is a continuation of application No. 14/871,020, filed on Sep. 30, 2015, granted, now 9,727,692, issued on Aug. 8, 2017.
Application 14/871,020 is a continuation of application No. 14/474,034, filed on Aug. 29, 2014, granted, now 9,183,496, issued on Nov. 10, 2015.
Claims priority of provisional application 61/872,611, filed on Aug. 30, 2013.
Prior Publication US 2021/0193260 A1, Jun. 24, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G16B 30/10 (2019.01); C12Q 1/68 (2018.01); G06N 3/126 (2023.01); G16B 20/00 (2019.01); G16B 20/20 (2019.01); G16B 30/00 (2019.01); G16H 50/00 (2018.01)
CPC G16B 30/10 (2019.02) [G06N 3/126 (2013.01); G16B 20/00 (2019.02); G16B 20/20 (2019.02); G16B 30/00 (2019.02); G16H 50/00 (2018.01); C12Q 1/68 (2013.01)] 20 Claims
 
1. A method for genetic analysis of a subject, comprising:
(a) subjecting a first nucleic acid sample of said subject to an untargeted sequencing reaction to generate a first set of sequencing data, wherein said first set of sequencing data comprises 300 megabases;
(b) subjecting a second nucleic acid sample of said subject to a target-specific sequencing reaction to generate a second set of sequencing data comprising RNA sequencing data; and
(c) using a computer to generate a combined output from said first set of sequencing data and said second set of sequencing data, which combined output is indicative of a presence or absence of one or more polymorphisms in at least a portion of a genome of said subject.