US 11,933,771 B2
Analysis control device, liquid chromatographic system and analysis execution method
Hiroyuki Minato, Kyoto (JP); and Masahide Gunji, Kyoto (JP)
Assigned to SHIMADZU CORPORATION, Kyoto (JP)
Appl. No. 17/413,808
Filed by SHIMADZU CORPORATION, Kyoto (JP)
PCT Filed Dec. 20, 2018, PCT No. PCT/JP2018/047088
§ 371(c)(1), (2) Date Jun. 14, 2021,
PCT Pub. No. WO2020/129223, PCT Pub. Date Jun. 25, 2020.
Prior Publication US 2022/0018818 A1, Jan. 20, 2022
Int. Cl. G01N 30/74 (2006.01); G01N 21/76 (2006.01); G01N 30/02 (2006.01); G01N 30/06 (2006.01); G01N 30/84 (2006.01); G01N 30/86 (2006.01)
CPC G01N 30/74 (2013.01) [G01N 30/8631 (2013.01); G01N 21/76 (2013.01); G01N 2030/027 (2013.01); G01N 30/06 (2013.01); G01N 30/84 (2013.01); G01N 30/86 (2013.01)] 5 Claims
OG exemplary drawing
 
1. An analysis control device that controls a liquid chromatograph including a first liquid sender, a second liquid sender, a sample introducer, an analysis column, a junction and a fluorescence detector, comprising:
a first liquid sending controller that controls the first liquid sender such that a mobile phase is supplied to the fluorescence detector through the analysis column and the junction during an analysis of a sample and during determination of an analysis condition;
a second liquid sending controller that controls the second liquid sender such that a fluorescent reaction liquid is supplied to the fluorescence detector through the junction during the analysis of the sample and during the determination of the analysis condition;
a sample introduction controller that controls the sample introducer such that the sample is introduced into the mobile phase by the sample introducer at a position farther upstream than the analysis column during the analysis of the sample and during the determination of the analysis condition;
a generator that generates a chromatogram based on an output signal of the fluorescence detector during the analysis of the sample and during the determination of the analysis condition; and
a supply period determiner that determines a period from a point in time at which the second liquid sender starts supplying the fluorescent reaction liquid to a point in time at which the second liquid sender ends supplying the fluorescent reaction liquid as a supply period based on the chromatogram generated by the generator during the determination of the analysis condition,
wherein the supply period determiner determines a start point in time of the supply period such that the fluorescent reaction liquid arrives at the junction later than a point in time at which supply of the mobile phase starts and before the sample introduced into the mobile phase arrives at the junction, and also determines a point in time after the sample passes through the junction as an end point in time of the supply period, and
the second liquid sending controller causes the second liquid sender to start supplying the fluorescent reaction liquid at the start point in time of the determined supply period and causes the second liquid sender to stop supplying the fluorescent reaction liquid at the end point in time of the supply period during the analysis of the sample.